The Resource A Structural Perspective on Respiratory Complex I : Structure and Function of NADH:ubiquinone oxidoreductase, edited by Leonid Sazanov, (electronic resource)

A Structural Perspective on Respiratory Complex I : Structure and Function of NADH:ubiquinone oxidoreductase, edited by Leonid Sazanov, (electronic resource)

Label
A Structural Perspective on Respiratory Complex I : Structure and Function of NADH:ubiquinone oxidoreductase
Title
A Structural Perspective on Respiratory Complex I
Title remainder
Structure and Function of NADH:ubiquinone oxidoreductase
Statement of responsibility
edited by Leonid Sazanov
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Complex I (NADH:ubiquinone oxidoreductase) is the first and largest enzyme of the respiratory chain in mitochondria and plays a central role in cellular energy production. Complex I dysfunction has been implicated in many human neurodegenerative diseases, including Parkinson’s. Mutations in complex I subunits are among the most common human genetic disorders known. Until recently, in the absence of structural information, complex I was the least understood enzyme of the respiratory chain. The mechanism by which it couples electron transfer between NADH and quinone to the translocation of protons across the membrane was a complete enigma. Recent years have been marked by spectacular progress in the elucidation of complex I’s structure, finally allowing the interpretation of a wealth of data accumulated in about 50 years since the discovery of the enzyme. Understanding of the mechanism of this large molecular machine, involving long-range conformational changes, is beginning to emerge. This book is the first devoted entirely to complex I. It contains chapters written by leaders in the field, covering a wide range of topics from the structure of the complex, properties of its many redox centers, subunit composition, mutagenesis studies, evolution of the enzyme and on to the current understanding of the coupling mechanism and the molecular basis for human pathologies. Features: - Concise and authoritative review of current state-of-the-art in research on respiratory complex I - The first book entirely devoted to complex I, a central enzyme in bioenergetics - Recent breakthroughs in structure elucidation finally allow understanding of the mechanism - Mutations leading to common and severe human disorders are discussed
Dewey number
615/.1
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
k6QQgMMXqac
Language note
English
LC call number
R-RZ
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Sazanov, Leonid.
http://library.link/vocab/subjectName
  • Medicine
  • Biochemistry
  • Cell membranes
  • Biomedicine general
  • Biochemistry, general
  • Protein Structure
  • Membrane Biology
  • Molecular Medicine
Label
A Structural Perspective on Respiratory Complex I : Structure and Function of NADH:ubiquinone oxidoreductase, edited by Leonid Sazanov, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
pt. 1. Structure and mechanism of complex I -- pt. 2. Evolution of complex I -- pt. 3. Mutations in complex I subunits and medical implications -- pt. 4. Subunit composition and assembly of mitochondrial complex I -- pt. 5. Supercomplexes in mitochondria
Dimensions
unknown
Edition
1st ed. 2012.
Extent
1 online resource (280 p.)
Form of item
online
Isbn
9789400741386
Media category
computer
Media type code
c
Other control number
10.1007/978-94-007-4138-6
Specific material designation
remote
System control number
  • (CKB)2550000000101287
  • (EBL)971827
  • (OCoLC)798208012
  • (SSID)ssj0000682221
  • (PQKBManifestationID)11365673
  • (PQKBTitleCode)TC0000682221
  • (PQKBWorkID)10678910
  • (PQKB)10892406
  • (DE-He213)978-94-007-4138-6
  • (MiAaPQ)EBC971827
  • (EXLCZ)992550000000101287
Label
A Structural Perspective on Respiratory Complex I : Structure and Function of NADH:ubiquinone oxidoreductase, edited by Leonid Sazanov, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
pt. 1. Structure and mechanism of complex I -- pt. 2. Evolution of complex I -- pt. 3. Mutations in complex I subunits and medical implications -- pt. 4. Subunit composition and assembly of mitochondrial complex I -- pt. 5. Supercomplexes in mitochondria
Dimensions
unknown
Edition
1st ed. 2012.
Extent
1 online resource (280 p.)
Form of item
online
Isbn
9789400741386
Media category
computer
Media type code
c
Other control number
10.1007/978-94-007-4138-6
Specific material designation
remote
System control number
  • (CKB)2550000000101287
  • (EBL)971827
  • (OCoLC)798208012
  • (SSID)ssj0000682221
  • (PQKBManifestationID)11365673
  • (PQKBTitleCode)TC0000682221
  • (PQKBWorkID)10678910
  • (PQKB)10892406
  • (DE-He213)978-94-007-4138-6
  • (MiAaPQ)EBC971827
  • (EXLCZ)992550000000101287

Library Locations

  • Albert D. Cohen Management LibraryBorrow it
    181 Freedman Crescent, Winnipeg, MB, R3T 5V4, CA
    49.807878 -97.129961
  • Architecture/Fine Arts LibraryBorrow it
    84 Curry Place, Winnipeg, MB, CA
    49.807716 -97.136226
  • Archives and Special CollectionsBorrow it
    25 Chancellors Circle (Elizabeth Dafoe Library), Room 330, Winnipeg, MB, R3T 2N2, CA
    49.809961 -97.131878
  • Bibliothèque Alfred-Monnin (Université de Saint-Boniface)Borrow it
    200, avenue de la Cathédrale, Local 2110, Winnipeg, MB, R2H 0H7, CA
    49.888861 -97.119735
  • Bill Larson Library (Grace Hospital)Borrow it
    300 Booth Drive, G-227, Winnipeg, MB, R3J 3M7, CA
    49.882400 -97.276436
  • Carolyn Sifton - Helene Fuld Library (St. Boniface General Hospital)Borrow it
    409 Tache Avenue, Winnipeg, MB, R2H 2A6, CA
    49.883388 -97.126050
  • Concordia Hospital LibraryBorrow it
    1095 Concordia Avenue, Winnipeg, MB, R2K 3S8, CA
    49.913252 -97.064683
  • Donald W. Craik Engineering LibraryBorrow it
    75B Chancellors Circle (Engineering Building E3), Room 361, Winnipeg, MB, R3T 2N2, CA
    49.809053 -97.133292
  • E.K. Williams Law LibraryBorrow it
    224 Dysart Road, Winnipeg, MB, R3T 5V4, CA
    49.811829 -97.131017
  • Eckhardt-Gramatté Music LibraryBorrow it
    136 Dafoe Road (Taché Arts Complex), Room 257, Winnipeg, MB, R3T 2N2, CA
    49.807964 -97.132222
  • Elizabeth Dafoe LibraryBorrow it
    25 Chancellors Circle, Winnipeg, MB, R3T 2N2, CA
    49.809961 -97.131878
  • Fr. H. Drake Library (St. Paul's College)Borrow it
    70 Dysart Road, Winnipeg, MB, R3T 2M6, CA
    49.810605 -97.138184
  • J.W. Crane Memorial Library (Deer Lodge Centre)Borrow it
    2109 Portage Avenue, Winnipeg, MB, R3J 0L3, CA
    49.878000 -97.235520
  • Libraries Annex (not open to the public; please see web page for details)Borrow it
    25 Chancellors Circle (in the Elizabeth Dafoe Library), Winnipeg, MB, R3T 2N2, CA
    49.809961 -97.131878
  • Neil John Maclean Health Sciences LibraryBorrow it
    727 McDermot Avenue (Brodie Centre), 200 Level, Winnipeg, MB, R3E 3P5, CA
    49.903563 -97.160554
  • Sciences and Technology LibraryBorrow it
    186 Dysart Road, Winnipeg, MB, R3T 2M8, CA
    49.811526 -97.133257
  • Seven Oaks General Hospital LibraryBorrow it
    2300 McPhillips Street, Winnipeg, MB, R2V 3M3, CA
    49.955177 -97.148865
  • Sister St. Odilon Library (Misericordia Health Centre)Borrow it
    99 Cornish Avenue, Winnipeg, MB, R3C 1A2, CA
    49.879592 -97.160425
  • St. John's College LibraryBorrow it
    92 Dysart Road, Winnipeg, MB, R3T 2M5, CA
    49.811242 -97.137156
  • Victoria General Hospital LibraryBorrow it
    2340 Pembina Highway, Winnipeg, MB, R3T 2E8, CA
    49.806755 -97.152739
  • William R Newman Library (Agriculture)Borrow it
    66 Dafoe Road, Winnipeg, MB, R3T 2R3, CA
    49.806936 -97.135525
Processing Feedback ...