The Resource ATP-gated P2X receptors in health and disease, topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin, (electronic resource)

ATP-gated P2X receptors in health and disease, topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin, (electronic resource)

Label
ATP-gated P2X receptors in health and disease
Title
ATP-gated P2X receptors in health and disease
Statement of responsibility
topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin
Contributor
Editor
Subject
Language
  • eng
  • eng
Summary
Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases
Cataloging source
PQKB
Illustrations
  • illustrations
  • charts
Index
no index present
Language note
English
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Khakh, Baljit S.
  • Nistri, Andrea
  • Burnstock, Geoffrey
  • Giniatullin, Rashid
Series statement
Frontiers Research Topics
http://library.link/vocab/subjectName
  • Neurology
  • Neurotransmitters
  • Medicine
  • Neurology
  • Medicine
  • Health & Biological Sciences
Target audience
specialized
Label
ATP-gated P2X receptors in health and disease, topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin, (electronic resource)
Instantiates
Publication
Copyright
Note
  • Bibliographic Level Mode of Issuance: Monograph
  • Published in Frontiers in Cellular Neuroscience
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Dimensions
unknown
Extent
1 online resource (172 pages)
Form of item
  • electronic
  • online
Isbn
9782889194056
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations, charts; digital, PDF file(s).
Specific material designation
remote
System control number
  • (CKB)3710000000526090
  • (SSID)ssj0001664966
  • (PQKBManifestationID)16454346
  • (PQKBTitleCode)TC0001664966
  • (PQKBWorkID)14999477
  • (PQKB)10870683
  • (EXLCZ)993710000000526090
System details
Mode of access: internet via World Wide Web
Label
ATP-gated P2X receptors in health and disease, topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin, (electronic resource)
Publication
Copyright
Note
  • Bibliographic Level Mode of Issuance: Monograph
  • Published in Frontiers in Cellular Neuroscience
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Dimensions
unknown
Extent
1 online resource (172 pages)
Form of item
  • electronic
  • online
Isbn
9782889194056
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations, charts; digital, PDF file(s).
Specific material designation
remote
System control number
  • (CKB)3710000000526090
  • (SSID)ssj0001664966
  • (PQKBManifestationID)16454346
  • (PQKBTitleCode)TC0001664966
  • (PQKBWorkID)14999477
  • (PQKB)10870683
  • (EXLCZ)993710000000526090
System details
Mode of access: internet via World Wide Web

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