The Resource Adhesion-GPCRs : Structure to Function, edited by Simon Yona, Martin Stacey, (electronic resource)

Adhesion-GPCRs : Structure to Function, edited by Simon Yona, Martin Stacey, (electronic resource)

Label
Adhesion-GPCRs : Structure to Function
Title
Adhesion-GPCRs
Title remainder
Structure to Function
Statement of responsibility
edited by Simon Yona, Martin Stacey
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation
Member of
Is Subseries of
Dewey number
  • 572/.69
  • 612.01575
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
  • EUu2-sMOgGE
  • D88zsh6rZSA
Language note
English
LC call number
QP34-38
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Yona, Simon.
  • Stacey, Martin.
Series statement
Advances in Experimental Medicine and Biology,
Series volume
706
http://library.link/vocab/subjectName
  • Human physiology
  • Medicine
  • Human Physiology
  • Biomedicine general
  • Molecular Medicine
Label
Adhesion-GPCRs : Structure to Function, edited by Simon Yona, Martin Stacey, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution -- 7TM-Cadherins: Developmental Roles and Future Challenges -- Latrophilin Signalling in Tissue Polarity and Morphogenesis -- GPS Proteolytic Cleavage of Adhesion-GPCRs -- The Latrophilins, “Split-Personality” Receptors -- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals -- Adhesion-GPCRs in the CNS -- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression -- Adhesion-GPCRs in Tumorigenesis -- Immunity and Adhesion-GPCRs -- CD97 in Leukocyte Trafficking -- The Role of CD97 in Regulating Adaptive T-Cell Responses -- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation -- Signal Transduction Mediated through Adhesion-GPCRs -- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 -- Adhesion-GPCRs in the Male Reproductive Tract
Dimensions
unknown
Extent
1 online resource (215 p.)
Form of item
online
Isbn
9781441979131
Media category
computer
Media type code
c
Other control number
10.1007/978-1-4419-7913-1
Specific material designation
remote
System control number
  • (CKB)2670000000096166
  • (EBL)763480
  • (OCoLC)771416250
  • (SSID)ssj0000506466
  • (PQKBManifestationID)11335535
  • (PQKBTitleCode)TC0000506466
  • (PQKBWorkID)10515073
  • (PQKB)11739566
  • (DE-He213)978-1-4419-7913-1
  • (MiAaPQ)EBC763480
  • (EXLCZ)992670000000096166
Label
Adhesion-GPCRs : Structure to Function, edited by Simon Yona, Martin Stacey, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution -- 7TM-Cadherins: Developmental Roles and Future Challenges -- Latrophilin Signalling in Tissue Polarity and Morphogenesis -- GPS Proteolytic Cleavage of Adhesion-GPCRs -- The Latrophilins, “Split-Personality” Receptors -- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals -- Adhesion-GPCRs in the CNS -- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression -- Adhesion-GPCRs in Tumorigenesis -- Immunity and Adhesion-GPCRs -- CD97 in Leukocyte Trafficking -- The Role of CD97 in Regulating Adaptive T-Cell Responses -- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation -- Signal Transduction Mediated through Adhesion-GPCRs -- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 -- Adhesion-GPCRs in the Male Reproductive Tract
Dimensions
unknown
Extent
1 online resource (215 p.)
Form of item
online
Isbn
9781441979131
Media category
computer
Media type code
c
Other control number
10.1007/978-1-4419-7913-1
Specific material designation
remote
System control number
  • (CKB)2670000000096166
  • (EBL)763480
  • (OCoLC)771416250
  • (SSID)ssj0000506466
  • (PQKBManifestationID)11335535
  • (PQKBTitleCode)TC0000506466
  • (PQKBWorkID)10515073
  • (PQKB)11739566
  • (DE-He213)978-1-4419-7913-1
  • (MiAaPQ)EBC763480
  • (EXLCZ)992670000000096166

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