The Resource Advances in Mitochondrial Medicine, edited by Roberto Scatena, Patrizia Bottoni, Bruno Giardina, (electronic resource)

Advances in Mitochondrial Medicine, edited by Roberto Scatena, Patrizia Bottoni, Bruno Giardina, (electronic resource)

Label
Advances in Mitochondrial Medicine
Title
Advances in Mitochondrial Medicine
Statement of responsibility
edited by Roberto Scatena, Patrizia Bottoni, Bruno Giardina
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology
Member of
Is Subseries of
Dewey number
  • 616.042
  • 616/.042
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
  • IZWpJgOgZs0
  • cMtRl_C2zFM
  • We29muHCLsg
Language note
English
LC call number
R-RZ
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Scatena, Roberto.
  • Bottoni, Patrizia.
  • Giardina, Bruno.
Series statement
Advances in Experimental Medicine and Biology,
Series volume
942
http://library.link/vocab/subjectName
  • Medicine
  • Oncology
  • Toxicology
  • Biochemistry
  • Biomedicine general
  • Cancer Research
  • Molecular Medicine
  • Pharmacology/Toxicology
  • Medical Biochemistry
Label
Advances in Mitochondrial Medicine, edited by Roberto Scatena, Patrizia Bottoni, Bruno Giardina, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
Section I – Physiology and structure of Mitochondria -- 1. The oxidative phosphorylation system in mammalian mitochondria -- 2. Physiology and pathophysiology of mitochondrial DNA -- 3. Mitochondrial calcium as a key regulator of mitochondrial activities -- 4. Mitochondria and Nitric Oxide: Chemistry and Pathophysiology -- 5. Mitochondria and reactive oxygen species - which role in physiology and pathophysiology? -- 6. Uncoupling proteins: molecular, functional, regulatory, physiological and pathological aspects -- 7. The mitochondrial pathways of apoptosis -- Section II – Mitochondria and disease -- 8. Inherited mitochondrial disorders -- 9. Mitochondria and metabolism diseases -- 10. Mitochondria and diabetes. An intriguing pathogenetic role -- 11. Mitochondria and heart diseases -- 12. Mitochondria in neurodegeneration -- 13. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation -- Section III – Mitochondria and Aging -- 14.Mitochondria and aging -- 15. Mitochondria and pharmacology. -16. Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors -- 17. Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms -- 18. Anthracyclines and mitochondria -- Section IV- Applications of Mitochondrial science -- 19. Mitochondrial proteomics approaches for new potential diagnostic and prognostic biomarkers in cancer -- 20. Mitochondria in Anthropology and forensic medicine.
Dimensions
unknown
Edition
1st ed. 2012.
Extent
1 online resource (458 p.)
Form of item
online
Isbn
9789400728691
Media category
computer
Media type code
c
Other control number
10.1007/978-94-007-2869-1
Specific material designation
remote
System control number
  • (CKB)2550000000098240
  • (EBL)971798
  • (OCoLC)781097436
  • (SSID)ssj0000654214
  • (PQKBManifestationID)11349370
  • (PQKBTitleCode)TC0000654214
  • (PQKBWorkID)10661695
  • (PQKB)10479230
  • (DE-He213)978-94-007-2869-1
  • (MiAaPQ)EBC971798
  • (EXLCZ)992550000000098240
Label
Advances in Mitochondrial Medicine, edited by Roberto Scatena, Patrizia Bottoni, Bruno Giardina, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
Section I – Physiology and structure of Mitochondria -- 1. The oxidative phosphorylation system in mammalian mitochondria -- 2. Physiology and pathophysiology of mitochondrial DNA -- 3. Mitochondrial calcium as a key regulator of mitochondrial activities -- 4. Mitochondria and Nitric Oxide: Chemistry and Pathophysiology -- 5. Mitochondria and reactive oxygen species - which role in physiology and pathophysiology? -- 6. Uncoupling proteins: molecular, functional, regulatory, physiological and pathological aspects -- 7. The mitochondrial pathways of apoptosis -- Section II – Mitochondria and disease -- 8. Inherited mitochondrial disorders -- 9. Mitochondria and metabolism diseases -- 10. Mitochondria and diabetes. An intriguing pathogenetic role -- 11. Mitochondria and heart diseases -- 12. Mitochondria in neurodegeneration -- 13. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation -- Section III – Mitochondria and Aging -- 14.Mitochondria and aging -- 15. Mitochondria and pharmacology. -16. Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors -- 17. Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms -- 18. Anthracyclines and mitochondria -- Section IV- Applications of Mitochondrial science -- 19. Mitochondrial proteomics approaches for new potential diagnostic and prognostic biomarkers in cancer -- 20. Mitochondria in Anthropology and forensic medicine.
Dimensions
unknown
Edition
1st ed. 2012.
Extent
1 online resource (458 p.)
Form of item
online
Isbn
9789400728691
Media category
computer
Media type code
c
Other control number
10.1007/978-94-007-2869-1
Specific material designation
remote
System control number
  • (CKB)2550000000098240
  • (EBL)971798
  • (OCoLC)781097436
  • (SSID)ssj0000654214
  • (PQKBManifestationID)11349370
  • (PQKBTitleCode)TC0000654214
  • (PQKBWorkID)10661695
  • (PQKB)10479230
  • (DE-He213)978-94-007-2869-1
  • (MiAaPQ)EBC971798
  • (EXLCZ)992550000000098240

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