The Resource Advances in genetics, Volume ninety-two, edited by Theodore Friedmann, Department of Pediatrics, University of California at San Diego, School of Medicine, CA, USA, Jay C. Dunlap, Department of Genetics, the Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Stephen F. Goodwin, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

Advances in genetics, Volume ninety-two, edited by Theodore Friedmann, Department of Pediatrics, University of California at San Diego, School of Medicine, CA, USA, Jay C. Dunlap, Department of Genetics, the Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Stephen F. Goodwin, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

Label
Advances in genetics, Volume ninety-two
Title
Advances in genetics
Title number
Volume ninety-two
Statement of responsibility
edited by Theodore Friedmann, Department of Pediatrics, University of California at San Diego, School of Medicine, CA, USA, Jay C. Dunlap, Department of Genetics, the Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Stephen F. Goodwin, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Title variation
Advances in genetics
Contributor
Editor
Subject
Genre
Language
eng
Member of
Cataloging source
MiAaPQ
Illustrations
illustrations
Index
index present
LC call number
QH430
LC item number
.A38 2015
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorDate
1935-
http://library.link/vocab/relatedWorkOrContributorName
  • Friedmann, Theodore
  • Dunlap, Jay C.
  • Goodwin, Stephen F.
Series statement
Advances in Genetics
Series volume
v.Volume 92
http://library.link/vocab/subjectName
  • Genetics
  • Zebra danio
  • Nervous system
  • Mental illness
  • Circadian rhythms
Label
Advances in genetics, Volume ninety-two, edited by Theodore Friedmann, Department of Pediatrics, University of California at San Diego, School of Medicine, CA, USA, Jay C. Dunlap, Department of Genetics, the Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Stephen F. Goodwin, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Contents
  • Front Cover; ADVANCES IN GENETICS, VOLUME 92; Advances in Genetics; Copyright; CONTENTS; CONTRIBUTORS; One - Understanding and Editing the Zebrafish Genome; 1. INTRODUCTION; 2. GENOMICS RESOURCES; 2.1 Zebrafish Information Network (ZFIN); 2.2 Genome Wiki; 2.3 Genome Browsers; 2.4 Stock Centers; 2.5 Zebrafish International Resource Center; 2.6 The European Zebrafish Resource Center; 2.7 The China Zebrafish Resource Center; 3. TRANSGENESIS VECTORS; 4. MUTAGENESIS RESOURCES; 4.1 Chemical Mutagenesis Resources; 4.2 Insertional Mutagenesis Resources; 4.2.1 FLIPTRAP
  • 4.2.2 Zebrafish Enhancer TRAP Lines Database (ZETRAP)4.2.3 Zfishbook; 4.2.4 Chen Lab Collection; 4.2.5 Tissue-Specific Cre Resources; 4.2.6 zTrap Database; 4.2.7 Zebrafish Enhancer Trap Database; 4.2.8 FISHTRAP Zebrafish Ds Insertion Database; 4.2.8.1 Morpholino-Mediated Targeted Gene Knockdown; 4.3 Generation of Genetic Mutants by Targeted Mutagenesis Approaches; 4.4 Zinc Finger Nucleases (ZFNs); 4.5 Transcription Activator-Like Effector Nucleases (TALENs); 4.6 CRISPR/Cas9-Mediated Genome Editing; 4.7 General Consideration in Choosing and Target Site and CRISPR/Cas9 Design Tools
  • 4.7.1 CRISPR Design Tool4.7.2 CRISPRSCAN; 4.7.3 CHOPCHOP; 4.7.4 CasBLASTR; 4.7.5 CRISPR RGEN Tools; 4.8 CRISPR/Cas9 Mutant Identification Methods; 4.9 Generation of Knock-in Zebrafish Using Genome-Editing Tools; 5. CONCLUSIONS AND FUTURE PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Two - Life without Food and the Implications for Neurodegeneration; 1. INTRODUCTION; 2. METABOLIC RESTRUCTURING DURING DIAPAUSE; 2.1 Hypometabolism in Dauer Worms; 2.2 Hypometabolism in Insects; 3. SAVING ENERGY BY MEANS OF NA+/K+ ATPASE DOWNREGULATION; 4. NEUROPROTECTION IN DORMANT STATES
  • 4.1 Neuroprotection during Hibernation and Torpor4.1.1 Neuroprotection and Excitotoxicity; 4.2 Neuroprotection during Diapause; 4.2.1 Dauer Entry Protects Dying Neurons from Degenerating; 4.2.2 Expression of Regenerative Genes during Diapause; ACKNOWLEDGMENTS; REFERENCES; Three - Decoding Advances in Psychiatric Genetics: A Focus on Neural Circuits in Rodent Models; 1. INTRODUCTION; 2. BRIEF OVERVIEW OF GENETICS OF SCZ; 2.1 Common, Low Penetrance, Single-Nucleotide Polymorphism (SNP) Variants; 2.2 Rare, Higher Penetrance Genetic Variants; 2.3 Genetic Pathway Analysis
  • 3. PUTTING PSYCHIATRIC GENETICS TO WORK3.1 Genome Editing; 3.1.1 The Dawn of Genetic Models in Rats; 3.1.2 Limitations; 3.1.3 Reducing Off-target Effects; 4. PRIORITIZING PHENOTYPING STRATEGIES FOR ANIMAL MODELS OF PSYCHIATRIC DISORDERS; 4.1 Circuit Dysfunction in SCZ; 4.2 Strategies for In vivo Circuit-Level Analysis in Genetic Models for SCZ; 4.3 The Hippocampal-Prefrontal Circuit in SCZ; 4.4 In vivo Circuit Dysfunction in Genetic Animal Models; 4.4.1 Sleep-related Network Activity in SCZ; 4.4.2 Perturbing Circuits in a Top-down Approach; 5. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES
  • Four - Around the Fungal Clock: Recent Advances in the Molecular Study of Circadian Clocks in Neurospora and Other ..
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (198 p.)
Form of item
online
Isbn
9780128040140
Media category
computer
Media MARC source
rdamedia
Specific material designation
remote
System control number
  • (CKB)3710000000527179
  • (EBL)4181354
  • (MiAaPQ)EBC4181354
  • (EXLCZ)993710000000527179
Label
Advances in genetics, Volume ninety-two, edited by Theodore Friedmann, Department of Pediatrics, University of California at San Diego, School of Medicine, CA, USA, Jay C. Dunlap, Department of Genetics, the Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Stephen F. Goodwin, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Contents
  • Front Cover; ADVANCES IN GENETICS, VOLUME 92; Advances in Genetics; Copyright; CONTENTS; CONTRIBUTORS; One - Understanding and Editing the Zebrafish Genome; 1. INTRODUCTION; 2. GENOMICS RESOURCES; 2.1 Zebrafish Information Network (ZFIN); 2.2 Genome Wiki; 2.3 Genome Browsers; 2.4 Stock Centers; 2.5 Zebrafish International Resource Center; 2.6 The European Zebrafish Resource Center; 2.7 The China Zebrafish Resource Center; 3. TRANSGENESIS VECTORS; 4. MUTAGENESIS RESOURCES; 4.1 Chemical Mutagenesis Resources; 4.2 Insertional Mutagenesis Resources; 4.2.1 FLIPTRAP
  • 4.2.2 Zebrafish Enhancer TRAP Lines Database (ZETRAP)4.2.3 Zfishbook; 4.2.4 Chen Lab Collection; 4.2.5 Tissue-Specific Cre Resources; 4.2.6 zTrap Database; 4.2.7 Zebrafish Enhancer Trap Database; 4.2.8 FISHTRAP Zebrafish Ds Insertion Database; 4.2.8.1 Morpholino-Mediated Targeted Gene Knockdown; 4.3 Generation of Genetic Mutants by Targeted Mutagenesis Approaches; 4.4 Zinc Finger Nucleases (ZFNs); 4.5 Transcription Activator-Like Effector Nucleases (TALENs); 4.6 CRISPR/Cas9-Mediated Genome Editing; 4.7 General Consideration in Choosing and Target Site and CRISPR/Cas9 Design Tools
  • 4.7.1 CRISPR Design Tool4.7.2 CRISPRSCAN; 4.7.3 CHOPCHOP; 4.7.4 CasBLASTR; 4.7.5 CRISPR RGEN Tools; 4.8 CRISPR/Cas9 Mutant Identification Methods; 4.9 Generation of Knock-in Zebrafish Using Genome-Editing Tools; 5. CONCLUSIONS AND FUTURE PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Two - Life without Food and the Implications for Neurodegeneration; 1. INTRODUCTION; 2. METABOLIC RESTRUCTURING DURING DIAPAUSE; 2.1 Hypometabolism in Dauer Worms; 2.2 Hypometabolism in Insects; 3. SAVING ENERGY BY MEANS OF NA+/K+ ATPASE DOWNREGULATION; 4. NEUROPROTECTION IN DORMANT STATES
  • 4.1 Neuroprotection during Hibernation and Torpor4.1.1 Neuroprotection and Excitotoxicity; 4.2 Neuroprotection during Diapause; 4.2.1 Dauer Entry Protects Dying Neurons from Degenerating; 4.2.2 Expression of Regenerative Genes during Diapause; ACKNOWLEDGMENTS; REFERENCES; Three - Decoding Advances in Psychiatric Genetics: A Focus on Neural Circuits in Rodent Models; 1. INTRODUCTION; 2. BRIEF OVERVIEW OF GENETICS OF SCZ; 2.1 Common, Low Penetrance, Single-Nucleotide Polymorphism (SNP) Variants; 2.2 Rare, Higher Penetrance Genetic Variants; 2.3 Genetic Pathway Analysis
  • 3. PUTTING PSYCHIATRIC GENETICS TO WORK3.1 Genome Editing; 3.1.1 The Dawn of Genetic Models in Rats; 3.1.2 Limitations; 3.1.3 Reducing Off-target Effects; 4. PRIORITIZING PHENOTYPING STRATEGIES FOR ANIMAL MODELS OF PSYCHIATRIC DISORDERS; 4.1 Circuit Dysfunction in SCZ; 4.2 Strategies for In vivo Circuit-Level Analysis in Genetic Models for SCZ; 4.3 The Hippocampal-Prefrontal Circuit in SCZ; 4.4 In vivo Circuit Dysfunction in Genetic Animal Models; 4.4.1 Sleep-related Network Activity in SCZ; 4.4.2 Perturbing Circuits in a Top-down Approach; 5. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES
  • Four - Around the Fungal Clock: Recent Advances in the Molecular Study of Circadian Clocks in Neurospora and Other ..
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (198 p.)
Form of item
online
Isbn
9780128040140
Media category
computer
Media MARC source
rdamedia
Specific material designation
remote
System control number
  • (CKB)3710000000527179
  • (EBL)4181354
  • (MiAaPQ)EBC4181354
  • (EXLCZ)993710000000527179

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