The Resource Affinity and efficacy : the components of drug-receptor interactions, Frederick J. Ehlert

Affinity and efficacy : the components of drug-receptor interactions, Frederick J. Ehlert

Label
Affinity and efficacy : the components of drug-receptor interactions
Title
Affinity and efficacy
Title remainder
the components of drug-receptor interactions
Statement of responsibility
Frederick J. Ehlert
Creator
Author
Subject
Genre
Language
  • eng
  • eng
Summary
The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug–receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book. The topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for active and inactive receptor states. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed
Cataloging source
MiAaPQ
http://library.link/vocab/creatorName
Ehlert, Frederick J
Dewey number
615.7/0452
Index
index present
Language note
English
LC call number
RM302.4
LC item number
.E35 2015
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/subjectName
Drug receptors
Label
Affinity and efficacy : the components of drug-receptor interactions, Frederick J. Ehlert
Instantiates
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Color
multicolored
Content category
text
Content type code
  • txt
Contents
pt. I. Ligand-gated ion channels. ch. 1. Ligand-gated ion channels -- ch. 2. Affinity and efficacy of orthosteric ligands at ligand-gated ion channels -- ch. 3. Competitive interactions between orthostheric ligands at ligand-gated ion channels -- ch. 4. Analysis of allosteric interactions at ligand-gated ion channels -- pt. II. G protein-coupled receptors. ch. 5. G protein-coupled receptors and G protein and arrestin signaling -- ch. 6. Affinity and efficacy of the agonist-receptor-G-protein interaction -- ch. 7. Estimating affinity and efficacy by reverse-engineering and response-clamp analysis -- ch. 8. Analysis of agonism and inverse agonism in signaling pathways that exhibit constitutive activity -- ch. 9. Analysis of ligand bias in receptor signaling through different G protein pathways -- ch. 10. Competitive interactions between orthosteric ligands in functional assays on G protein-coupled receptors -- ch. 11. Analysis of allosterism in functional assays on G protein-coupled receptors -- pt. III. Radioligand binding. ch. 12. Analysis of drug-receptor interactions using radioligand binding assays on G protein-coupled receptors
Dimensions
unknown
Extent
1 online resource (750 p.)
Form of item
online
Isbn
9789814324229
Media category
computer
Media type code
  • c
Sound
unknown sound
Specific material designation
remote
System control number
  • (CKB)3710000000316250
  • (CaPaEBR)ebrary10998224
  • (SSID)ssj0001223683
  • (PQKBManifestationID)12456822
  • (PQKBTitleCode)TC0001223683
  • (PQKBWorkID)11260166
  • (PQKB)10453988
  • (MiAaPQ)EBC3051413
  • (WSP)00007888
  • (EXLCZ)993710000000316250
Label
Affinity and efficacy : the components of drug-receptor interactions, Frederick J. Ehlert
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Color
multicolored
Content category
text
Content type code
  • txt
Contents
pt. I. Ligand-gated ion channels. ch. 1. Ligand-gated ion channels -- ch. 2. Affinity and efficacy of orthosteric ligands at ligand-gated ion channels -- ch. 3. Competitive interactions between orthostheric ligands at ligand-gated ion channels -- ch. 4. Analysis of allosteric interactions at ligand-gated ion channels -- pt. II. G protein-coupled receptors. ch. 5. G protein-coupled receptors and G protein and arrestin signaling -- ch. 6. Affinity and efficacy of the agonist-receptor-G-protein interaction -- ch. 7. Estimating affinity and efficacy by reverse-engineering and response-clamp analysis -- ch. 8. Analysis of agonism and inverse agonism in signaling pathways that exhibit constitutive activity -- ch. 9. Analysis of ligand bias in receptor signaling through different G protein pathways -- ch. 10. Competitive interactions between orthosteric ligands in functional assays on G protein-coupled receptors -- ch. 11. Analysis of allosterism in functional assays on G protein-coupled receptors -- pt. III. Radioligand binding. ch. 12. Analysis of drug-receptor interactions using radioligand binding assays on G protein-coupled receptors
Dimensions
unknown
Extent
1 online resource (750 p.)
Form of item
online
Isbn
9789814324229
Media category
computer
Media type code
  • c
Sound
unknown sound
Specific material designation
remote
System control number
  • (CKB)3710000000316250
  • (CaPaEBR)ebrary10998224
  • (SSID)ssj0001223683
  • (PQKBManifestationID)12456822
  • (PQKBTitleCode)TC0001223683
  • (PQKBWorkID)11260166
  • (PQKB)10453988
  • (MiAaPQ)EBC3051413
  • (WSP)00007888
  • (EXLCZ)993710000000316250

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