The Resource Alzheimer's Disease : Methods and Protocols, edited by Nigel M. Hooper, (electronic resource)

Alzheimer's Disease : Methods and Protocols, edited by Nigel M. Hooper, (electronic resource)

Label
Alzheimer's Disease : Methods and Protocols
Title
Alzheimer's Disease
Title remainder
Methods and Protocols
Statement of responsibility
edited by Nigel M. Hooper
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert who uses it on a day-to-day basis. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagants and of amplification systems. Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy. Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today‚s diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge
Member of
Is Subseries of
Dewey number
616/.01
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
mN5BR8vmyFk
Language note
English
LC call number
RC346-429.2
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Hooper, Nigel M.
Series statement
Methods in Molecular Medicine,
Series volume
32
http://library.link/vocab/subjectName
  • Neurology
  • Neurology
Label
Alzheimer's Disease : Methods and Protocols, edited by Nigel M. Hooper, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
to Alzheimer's Disease -- The Genetics of Alzheimer's Disease -- Advances in Methodology and Current Prospects for Primary Drug Therapies for Alzheimer's Disease -- Production and Functional Assays of Recombinant Secreted Amyloid Precursor Protein (APP) (sAPP?) -- Quantifying A?1–40 and A?1–42 Using Sandwich-ELISA -- Electrophoretic Separation and Immunoblotting of A?1–40 and A?1–42 -- A?-Induced Proinflammatory Cytokine Release from Differentiated Human THP-1 Monocytes -- Effects of the ?-Amyloid Peptide on Membrane Ion Permeability -- Analysis of ?-Amyloid Peptide Degradation In Vitro -- Posttranslational Modifications of Amyloid Precursor Protein -- Posttranslational Modifications of the Amyloid Precursor Protein -- Using an Amyloid Precursor Protein (APP) Reporter to Characterize ?-Secretase -- Inhibition of ?-Secretase by Zinc Metalloproteinase Inhibitors -- Development of Neoepitope Antibodies Against the ?-Secretase Cleavage Site in the Amyloid Precursor Protein -- ?-Secretase -- Using ?-Secretase Inhibitors to Distiguish the Generation of the A? Peptides Terminating at Val-40 and Ala-42 -- Designing Animal Models of Alzheimer's Disease with Amyloid Precursor Protein (APP) Transgenes -- Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins -- Determining the Transmembrane Topology of the Presenilins -- Normal Proteolytic Processing of the Presenilins -- Apoptotic Proteolytic Cleavage of the Presenilins by Caspases -- The Phosphorylation of Presenilin Proteins -- Interaction of the Presenilins with the Amyloid Precursor Protein (APP) -- Distribution of Presenilins and Amyloid Precursor Protein (APP) in Detergent-Insoluble Membrane Domains -- Characterization and Use of Monoclonal Antibodies to Tau and Paired Helical Filament Tau -- Tau Phosphorylation Both In Vitro and in Cells -- Transglutaminase-Catalyzed Formation of Alzheimer-Like Insoluble Complexes from Recombinant Tau
Dimensions
unknown
Extent
1 online resource (424 p.)
Form of item
online
Isbn
9781280821554
Media category
computer
Media type code
c
Other control number
10.1385/1592591957
Specific material designation
remote
System control number
  • (CKB)111056486881108
  • (EBL)3037003
  • (SSID)ssj0000101708
  • (PQKBManifestationID)11108549
  • (PQKBTitleCode)TC0000101708
  • (PQKBWorkID)10042954
  • (PQKB)10330319
  • (MiAaPQ)EBC3037003
  • (DE-He213)978-1-59259-195-4
  • (EXLCZ)99111056486881108
Label
Alzheimer's Disease : Methods and Protocols, edited by Nigel M. Hooper, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
to Alzheimer's Disease -- The Genetics of Alzheimer's Disease -- Advances in Methodology and Current Prospects for Primary Drug Therapies for Alzheimer's Disease -- Production and Functional Assays of Recombinant Secreted Amyloid Precursor Protein (APP) (sAPP?) -- Quantifying A?1–40 and A?1–42 Using Sandwich-ELISA -- Electrophoretic Separation and Immunoblotting of A?1–40 and A?1–42 -- A?-Induced Proinflammatory Cytokine Release from Differentiated Human THP-1 Monocytes -- Effects of the ?-Amyloid Peptide on Membrane Ion Permeability -- Analysis of ?-Amyloid Peptide Degradation In Vitro -- Posttranslational Modifications of Amyloid Precursor Protein -- Posttranslational Modifications of the Amyloid Precursor Protein -- Using an Amyloid Precursor Protein (APP) Reporter to Characterize ?-Secretase -- Inhibition of ?-Secretase by Zinc Metalloproteinase Inhibitors -- Development of Neoepitope Antibodies Against the ?-Secretase Cleavage Site in the Amyloid Precursor Protein -- ?-Secretase -- Using ?-Secretase Inhibitors to Distiguish the Generation of the A? Peptides Terminating at Val-40 and Ala-42 -- Designing Animal Models of Alzheimer's Disease with Amyloid Precursor Protein (APP) Transgenes -- Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins -- Determining the Transmembrane Topology of the Presenilins -- Normal Proteolytic Processing of the Presenilins -- Apoptotic Proteolytic Cleavage of the Presenilins by Caspases -- The Phosphorylation of Presenilin Proteins -- Interaction of the Presenilins with the Amyloid Precursor Protein (APP) -- Distribution of Presenilins and Amyloid Precursor Protein (APP) in Detergent-Insoluble Membrane Domains -- Characterization and Use of Monoclonal Antibodies to Tau and Paired Helical Filament Tau -- Tau Phosphorylation Both In Vitro and in Cells -- Transglutaminase-Catalyzed Formation of Alzheimer-Like Insoluble Complexes from Recombinant Tau
Dimensions
unknown
Extent
1 online resource (424 p.)
Form of item
online
Isbn
9781280821554
Media category
computer
Media type code
c
Other control number
10.1385/1592591957
Specific material designation
remote
System control number
  • (CKB)111056486881108
  • (EBL)3037003
  • (SSID)ssj0000101708
  • (PQKBManifestationID)11108549
  • (PQKBTitleCode)TC0000101708
  • (PQKBWorkID)10042954
  • (PQKB)10330319
  • (MiAaPQ)EBC3037003
  • (DE-He213)978-1-59259-195-4
  • (EXLCZ)99111056486881108

Library Locations

  • Albert D. Cohen Management LibraryBorrow it
    181 Freedman Crescent, Winnipeg, MB, R3T 5V4, CA
    49.807878 -97.129961
  • Architecture/Fine Arts LibraryBorrow it
    84 Curry Place, Winnipeg, MB, CA
    49.807716 -97.136226
  • Archives and Special CollectionsBorrow it
    25 Chancellors Circle (Elizabeth Dafoe Library), Room 330, Winnipeg, MB, R3T 2N2, CA
    49.809961 -97.131878
  • Bibliothèque Alfred-Monnin (Université de Saint-Boniface)Borrow it
    200, avenue de la Cathédrale, Local 2110, Winnipeg, MB, R2H 0H7, CA
    49.888861 -97.119735
  • Bill Larson Library (Grace Hospital)Borrow it
    300 Booth Drive, G-227, Winnipeg, MB, R3J 3M7, CA
    49.882400 -97.276436
  • Carolyn Sifton - Helene Fuld Library (St. Boniface General Hospital)Borrow it
    409 Tache Avenue, Winnipeg, MB, R2H 2A6, CA
    49.883388 -97.126050
  • Concordia Hospital LibraryBorrow it
    1095 Concordia Avenue, Winnipeg, MB, R2K 3S8, CA
    49.913252 -97.064683
  • Donald W. Craik Engineering LibraryBorrow it
    75B Chancellors Circle (Engineering Building E3), Room 361, Winnipeg, MB, R3T 2N2, CA
    49.809053 -97.133292
  • E.K. Williams Law LibraryBorrow it
    224 Dysart Road, Winnipeg, MB, R3T 5V4, CA
    49.811829 -97.131017
  • Eckhardt-Gramatté Music LibraryBorrow it
    136 Dafoe Road (Taché Arts Complex), Room 257, Winnipeg, MB, R3T 2N2, CA
    49.807964 -97.132222
  • Elizabeth Dafoe LibraryBorrow it
    25 Chancellors Circle, Winnipeg, MB, R3T 2N2, CA
    49.809961 -97.131878
  • Fr. H. Drake Library (St. Paul's College)Borrow it
    70 Dysart Road, Winnipeg, MB, R3T 2M6, CA
    49.810605 -97.138184
  • J.W. Crane Memorial Library (Deer Lodge Centre)Borrow it
    2109 Portage Avenue, Winnipeg, MB, R3J 0L3, CA
    49.878000 -97.235520
  • Libraries Annex (not open to the public; please see web page for details)Borrow it
    25 Chancellors Circle (in the Elizabeth Dafoe Library), Winnipeg, MB, R3T 2N2, CA
    49.809961 -97.131878
  • Neil John Maclean Health Sciences LibraryBorrow it
    727 McDermot Avenue (Brodie Centre), 200 Level, Winnipeg, MB, R3E 3P5, CA
    49.903563 -97.160554
  • Sciences and Technology LibraryBorrow it
    186 Dysart Road, Winnipeg, MB, R3T 2M8, CA
    49.811526 -97.133257
  • Seven Oaks General Hospital LibraryBorrow it
    2300 McPhillips Street, Winnipeg, MB, R2V 3M3, CA
    49.955177 -97.148865
  • Sister St. Odilon Library (Misericordia Health Centre)Borrow it
    99 Cornish Avenue, Winnipeg, MB, R3C 1A2, CA
    49.879592 -97.160425
  • St. John's College LibraryBorrow it
    92 Dysart Road, Winnipeg, MB, R3T 2M5, CA
    49.811242 -97.137156
  • Victoria General Hospital LibraryBorrow it
    2340 Pembina Highway, Winnipeg, MB, R3T 2E8, CA
    49.806755 -97.152739
  • William R Newman Library (Agriculture)Borrow it
    66 Dafoe Road, Winnipeg, MB, R3T 2R3, CA
    49.806936 -97.135525
Processing Feedback ...