The Resource Biologic response modifier agents as first-line treatment for patients with rheumatoid arthritis : a review of the clinical efficacy, cost-effectiveness and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Biologic response modifier agents as first-line treatment for patients with rheumatoid arthritis : a review of the clinical efficacy, cost-effectiveness and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Label
Biologic response modifier agents as first-line treatment for patients with rheumatoid arthritis : a review of the clinical efficacy, cost-effectiveness and guidelines
Title
Biologic response modifier agents as first-line treatment for patients with rheumatoid arthritis
Title remainder
a review of the clinical efficacy, cost-effectiveness and guidelines
Statement of responsibility
[prepared by Canadian Agency for Drugs and Technologies in Health]
Contributor
Subject
Genre
Language
eng
Summary
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects approximately 300,000 Canadians. It is characterized by pain, swelling and progressive joint damage, an increase in morbidity and mortality, and a reduction in quality of life and daily activities. Traditional disease modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX), leflunomide, sulfasalazine and hydroxychloroquine, have been shown to modify the clinical course of RA and to slow or stop radiographic progression. The newer biologic disease modifying agents target specific mechanisms of inflammation and have increased the therapeutic options for patients with RA. In Canada, these agents include the tumor necrosis factor (TNF) inhibitors (adalimumab, etanercept, infliximab, golimumab, and certolizumab), T cell costimulatory inhibitor (abatacept), B lymphocyte-depleting agent (rituximab), interleukin 6 antagonist (tocilizumab) and interleukin 1 inhibitor (anakinra). Based on a CADTH therapeutic review completed in 2010, biologic agents were recommended for use in adults with RA who had an inadequate response to optimal doses of DMARDs. Since that review, a number of studies have been published including trials in patients who are DMARD nav̐e. There are outstanding questions regarding the optimal use of biologic agents, as earlier and more aggressive treatment strategies are being used in clinical practice. This report will review the evidence on the clinical efficacy, cost-effectiveness and guidelines for use of biologic agents as first line therapy in adults with RA
Member of
Cataloging source
CaBNVSL
Dewey number
615.7
Illustrations
illustrations
Index
no index present
LC call number
RM405
LC item number
.B568 2013eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 247
NLM item number
B568 2013eb
http://library.link/vocab/relatedWorkOrContributorName
  • Canadian Agency for Drugs and Technologies in Health
  • Canadian Electronic Library (Firm)
Series statement
Rapid response report, summary with critical appraisal
http://library.link/vocab/subjectName
  • Rheumatoid arthritis
  • Antirheumatic agents
  • Arthritis, Rheumatoid
  • Antirheumatic Agents
Label
Biologic response modifier agents as first-line treatment for patients with rheumatoid arthritis : a review of the clinical efficacy, cost-effectiveness and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/237322
Instantiates
Publication
Note
  • "06 March 2013"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 14-16)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (48 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
237322
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00555835
  • (OCoLC)848003090
  • (CaOOCEL)237322
System details
Mode of access: World Wide Web
Label
Biologic response modifier agents as first-line treatment for patients with rheumatoid arthritis : a review of the clinical efficacy, cost-effectiveness and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/237322
Publication
Note
  • "06 March 2013"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 14-16)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (48 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
237322
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00555835
  • (OCoLC)848003090
  • (CaOOCEL)237322
System details
Mode of access: World Wide Web

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