The Resource Bone and osteoarthritis, Felix Bronner and Mary C. Farach-Carson, (eds.), (electronic resource)

Bone and osteoarthritis, Felix Bronner and Mary C. Farach-Carson, (eds.), (electronic resource)

Label
Bone and osteoarthritis
Title
Bone and osteoarthritis
Statement of responsibility
Felix Bronner and Mary C. Farach-Carson, (eds.)
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease. A novel aspect is the attention given to the possible epigenetic basis, together with a discussion of the genetics predisposing to osteoarthritis. Detailed analyses are given of the role of the synovium, of the molecular mechanisms that lead to degradation of the cartilage matrix, of the hypertrophy of the cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to novel approaches to clinical treatment, utilizing anabolic mediators or molecules that target steps in the disease process. Also discussed are animal models and how mechano-responsiveness is compromised by mechanical injury. Orthopedics and rheumatology have become close conceptually, as advances in bone and joint biology have enabled bench and translational scientists, as well as practitioners, to approach clinical problems comprehensively. Because bone plays a role in initiating osteoarthritis, therapeutic approaches focusing on bone tissue are included in the discussion of novel treatments. The general topic of osteoarthritis is therefore a timely subject for a series on bone biology. This book, intended for clinicians, researchers and students, provides information that will orient the novice and update the specialist. No other book treats the relationship of bone to osteoarthritis in similar fashion or provides a comparable underpinning of joint pathophysiology
Member of
Cataloging source
MiAaPQ
Dewey number
616.7/23071
Illustrations
illustrations
Index
index present
Language note
English
LC call number
RC931.O67
LC item number
B66 2007
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorDate
1958-
http://library.link/vocab/relatedWorkOrContributorName
  • Bronner, Felix
  • Farach-Carson, Mary C.
Series statement
Topics in bone biology
Series volume
v. 4
http://library.link/vocab/subjectName
  • Osteoarthritis
  • Bone
Label
Bone and osteoarthritis, Felix Bronner and Mary C. Farach-Carson, (eds.), (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
The Pathogenesis of Osteoarthritis -- The Role of Bone in the Development of Osteoarthritis -- Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage -- The Synovium and Its Role in Osteoarthritis -- Cartilage Matrix Destruction -- Anabolic Mediators of Cartilage Healing -- Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface -- Genetic and Epigenetic Aspects of Osteoarthritis -- Animal Models -- Biomechanical Aspects: Joint Injury and Osteoarthritis -- Novel Osteoarthritis Therapeutics
Dimensions
unknown
Extent
1 online resource (219 p.)
Form of item
online
Isbn
9781846287015
Media category
computer
Media type code
c
Other control number
10.1007/978-1-84628-701-5
Specific material designation
remote
System control number
  • (CKB)1000000000492520
  • (EBL)603708
  • (OCoLC)813244264
  • (SSID)ssj0000319317
  • (PQKBManifestationID)11250098
  • (PQKBTitleCode)TC0000319317
  • (PQKBWorkID)10336854
  • (PQKB)10311630
  • (DE-He213)978-1-84628-701-5
  • (MiAaPQ)EBC603708
  • (EXLCZ)991000000000492520
Label
Bone and osteoarthritis, Felix Bronner and Mary C. Farach-Carson, (eds.), (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
The Pathogenesis of Osteoarthritis -- The Role of Bone in the Development of Osteoarthritis -- Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage -- The Synovium and Its Role in Osteoarthritis -- Cartilage Matrix Destruction -- Anabolic Mediators of Cartilage Healing -- Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface -- Genetic and Epigenetic Aspects of Osteoarthritis -- Animal Models -- Biomechanical Aspects: Joint Injury and Osteoarthritis -- Novel Osteoarthritis Therapeutics
Dimensions
unknown
Extent
1 online resource (219 p.)
Form of item
online
Isbn
9781846287015
Media category
computer
Media type code
c
Other control number
10.1007/978-1-84628-701-5
Specific material designation
remote
System control number
  • (CKB)1000000000492520
  • (EBL)603708
  • (OCoLC)813244264
  • (SSID)ssj0000319317
  • (PQKBManifestationID)11250098
  • (PQKBTitleCode)TC0000319317
  • (PQKBWorkID)10336854
  • (PQKB)10311630
  • (DE-He213)978-1-84628-701-5
  • (MiAaPQ)EBC603708
  • (EXLCZ)991000000000492520

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