The Resource Bone morphogenetic proteins for use in spinal surgery and long bone trauma surgery : a review of the clinical effectiveness and safety, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Bone morphogenetic proteins for use in spinal surgery and long bone trauma surgery : a review of the clinical effectiveness and safety, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Label
Bone morphogenetic proteins for use in spinal surgery and long bone trauma surgery : a review of the clinical effectiveness and safety
Title
Bone morphogenetic proteins for use in spinal surgery and long bone trauma surgery
Title remainder
a review of the clinical effectiveness and safety
Statement of responsibility
[prepared by Canadian Agency for Drugs and Technologies in Health]
Contributor
Subject
Genre
Language
eng
Summary
Bone morphogenetic proteins (BMPs) are a group of growth factors capable of inducing the formation of bone. In addition to other vital tissue development functions, these proteins signal new bone growth through multiple pathways during the healing of bone. Osteoblasts are one cell type that respond to BMP signaling and are directly responsible for deposition of new bone. BMPs induce the differentiation of osetoprogenetor cells into osteoblasts and stimulate migration of these cells to areas of repair leading to the formation of new bone. Formation of new bone is critical for surgical success in spinal fusion surgeries and in the treatment of nonunion of fractured limbs. In order to achieve sufficient production of new bone for these procedures a bone graft can be used to induce new bone formation. More recently, application of recombinant human BMPs has been an available alternative or adjunct to bone graft procedures in order to achieve sufficient new bone formation. As with many growth factors, disruption of normal BMP signaling is routinely found in tumour cells. Therefore at therapeutic doses the potential of exogenous BMPs to increase cancer incidence is a logical concern. Additional potential adverse events specific to these biotherapeutics must also be evaluated before their use is considered in any application. The purpose of this report is to retrieve and review the existing evidence on clinical effectiveness and safety of BMPs for use in spinal fusion surgery and treatment of long bone trauma
Member of
Cataloging source
CaBNVSL
Dewey number
616.7/1061
Illustrations
illustrations
Index
no index present
LC call number
QP552.B65
LC item number
B654 2013eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WE 168
NLM item number
B654 2013eb
http://library.link/vocab/relatedWorkOrContributorName
  • Canadian Agency for Drugs and Technologies in Health
  • Canadian Electronic Library (Firm)
Series statement
Rapid response report, summary with critical appraisal
http://library.link/vocab/subjectName
  • Bone morphogenetic proteins
  • Bone morphogenetic proteins
  • Spine
  • Bones
  • Bone Morphogenetic Proteins
  • Spine
  • Bone and Bones
  • Osteogenesis
Label
Bone morphogenetic proteins for use in spinal surgery and long bone trauma surgery : a review of the clinical effectiveness and safety, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/237320
Instantiates
Publication
Note
  • "08 March 2013"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 10-12)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (39 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
237320
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00555833
  • (OCoLC)848003308
  • (CaOOCEL)237320
System details
Mode of access: World Wide Web
Label
Bone morphogenetic proteins for use in spinal surgery and long bone trauma surgery : a review of the clinical effectiveness and safety, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/237320
Publication
Note
  • "08 March 2013"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 10-12)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (39 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
237320
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00555833
  • (OCoLC)848003308
  • (CaOOCEL)237320
System details
Mode of access: World Wide Web

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