The Resource Cancer and development, edited by Michael A. Dyer, (electronic resource)

Cancer and development, edited by Michael A. Dyer, (electronic resource)

Label
Cancer and development
Title
Cancer and development
Statement of responsibility
edited by Michael A. Dyer
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
In recent years, a number of molecular pathways and cellular processes that are essential for normal vertebrate development have been implicated in cancer initiation and progression. In this volume, leaders in the field of cancer genetics and developmental biology share recent insights into the importance of developmental pathways for tumorigenesis. These discoveries provide important avenues for innovative new approaches to treating some of the most challenging developmental tumors. Provides researchers an overview and synthesis of the latest research findings and contem
Member of
Is Subseries of
Cataloging source
MiAaPQ
Dewey number
  • 571.81
  • 616.994042
Illustrations
  • illustrations
  • plates
Index
index present
Language note
English
LC call number
RC261
LC item number
.C36 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Dyer, Michael A
Series statement
Current topics in developmental biology,
Series volume
v. 94
http://library.link/vocab/subjectName
  • Cancer
  • Developmental biology
  • Tumors
Label
Cancer and development, edited by Michael A. Dyer, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Front Cover; Current Topics in Developmental Biology: Cancer and Development; Copyright; Contents; Contributors; Preface; Chapter 1: Childhood Cancer and Developmental Biology: A Crucial Partnership; 1. Introduction; 2. Developmental Biology and Cancer Genetics; 3. Clinical Features of Retinoblastoma; 4. Mouse Models of Pediatric Cancer; 5. Translational Research: Is It Clinically Relevant?; 6. Immortalized Cell Lines; 7. Xenograft Models; 8. Genetically Engineered Mouse Models; 9. Comprehensive Preclinical Trials; 10. Summary; References; Chapter 2: Stem Cells in Brain Tumor Development
  • 1. Introduction2. Genetic Pathways in Malignant Glioma; 3. Mouse Models of Malignant Glioma; 4. Neural Stem Cells in the Mammalian Brain; 5. NSCs as Cells of Origin of Malignant Astrocytoma; 6. Cancer Stem Cells in Malignant Glioma Progression; 7. Classical Developmental Pathways in Neurogenesis and Gliomagenesis; 9. Summary and Perspective: CNS and Brain Tumor Development; Acknowledgments; Chapter 3: MDM2 and MDMX in Cancer and Development; 1. Introduction; 2. The p53-Mdm2 Network; 3. Mdmx, an Mdm2 Relative; 4. Mdmx, Another Key Regulator of p53
  • 5. Regulation of Mdm2-Mediated p53 Ubiquitylation6. Regulation of Mdm2 Stability; 7. Regulation of Mdm2 Localization; 8. Other Mdm2 Binding Proteins Acting in the p53 Pathway; 9. Regulation of Mdmx Expression and Activity; 10. The Mdm2-Mdmx-p53 Network and Cancer Development; 11. Mdmx as the First Specific Drug Target for Treating Retinoblastoma; 12. The Mdmx-Mdm2-p53 Interplay as a Target for Therapeutic Intervention; References; Chapter 4: The Connections Between Neural Crest Development and Neuroblastoma; 1. Clinical and Biological Characteristics of Neuroblastoma (NB)
  • 2. Neural Development and NB3. Genetic Lesions in NB; 4. The Role of Neurotrophins and Growth Factors in the Development of the Sympathetic Nervous System and in NB; 5. Programmed Cell Death (PCD; Apoptosis) in Development of NB; 6. The Role of Epithelial to Mesenchymal Transition (EMT) in Development and Metastasis; 7. The Role of miRNA in Development and NB; 8. Other Important Genes in NB; 9. Clinical Treatment Overview; 10. Conclusion; Acknowledgments; References; Chapter 5: RB1, Development, and Cancer; 1. Introduction; 2. The Pocket Proteins; 3. The pRb/E2F Cell Cycle Switch
  • 4. Evolutionary Conservation of the Switch5. Variations on the Switch; 6. Rb1 Function Beyond Transcription; 7. Rb1, Stem Cells, and the Cell of Tumor Origin; 8. Rb1 and Tumor Progression; 9. Summary; Acknowledgments; References; Chapter 6: Genetic Alterations Targeting Lymphoid Development in Acute Lymphoblastic Leukemia; 1. Introduction; 2. Genetics of ALL; 3. Lymphoid Development; 4. Genome-Wide Profiling of Genetic Alterations in Cancer; 5. Genome-Wide Profiling of Genetic Alterations in ALL; 6. Genetic Alterations Targeting Lymphoid Development in B-ALL
  • 7. IKZF1 Alterations in BCR-ABL1 Positive ALL
Dimensions
unknown
Edition
1st ed.
Extent
1 online resource (397 p.)
Form of item
online
Isbn
9780123809179
Media category
computer
Media type code
c
Specific material designation
remote
System control number
  • (CKB)3390000000006044
  • (EBL)680861
  • (OCoLC)741491867
  • (SSID)ssj0000521346
  • (PQKBManifestationID)12205186
  • (PQKBTitleCode)TC0000521346
  • (PQKBWorkID)10518384
  • (PQKB)10518714
  • (MiAaPQ)EBC680861
  • (EXLCZ)993390000000006044
Label
Cancer and development, edited by Michael A. Dyer, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Front Cover; Current Topics in Developmental Biology: Cancer and Development; Copyright; Contents; Contributors; Preface; Chapter 1: Childhood Cancer and Developmental Biology: A Crucial Partnership; 1. Introduction; 2. Developmental Biology and Cancer Genetics; 3. Clinical Features of Retinoblastoma; 4. Mouse Models of Pediatric Cancer; 5. Translational Research: Is It Clinically Relevant?; 6. Immortalized Cell Lines; 7. Xenograft Models; 8. Genetically Engineered Mouse Models; 9. Comprehensive Preclinical Trials; 10. Summary; References; Chapter 2: Stem Cells in Brain Tumor Development
  • 1. Introduction2. Genetic Pathways in Malignant Glioma; 3. Mouse Models of Malignant Glioma; 4. Neural Stem Cells in the Mammalian Brain; 5. NSCs as Cells of Origin of Malignant Astrocytoma; 6. Cancer Stem Cells in Malignant Glioma Progression; 7. Classical Developmental Pathways in Neurogenesis and Gliomagenesis; 9. Summary and Perspective: CNS and Brain Tumor Development; Acknowledgments; Chapter 3: MDM2 and MDMX in Cancer and Development; 1. Introduction; 2. The p53-Mdm2 Network; 3. Mdmx, an Mdm2 Relative; 4. Mdmx, Another Key Regulator of p53
  • 5. Regulation of Mdm2-Mediated p53 Ubiquitylation6. Regulation of Mdm2 Stability; 7. Regulation of Mdm2 Localization; 8. Other Mdm2 Binding Proteins Acting in the p53 Pathway; 9. Regulation of Mdmx Expression and Activity; 10. The Mdm2-Mdmx-p53 Network and Cancer Development; 11. Mdmx as the First Specific Drug Target for Treating Retinoblastoma; 12. The Mdmx-Mdm2-p53 Interplay as a Target for Therapeutic Intervention; References; Chapter 4: The Connections Between Neural Crest Development and Neuroblastoma; 1. Clinical and Biological Characteristics of Neuroblastoma (NB)
  • 2. Neural Development and NB3. Genetic Lesions in NB; 4. The Role of Neurotrophins and Growth Factors in the Development of the Sympathetic Nervous System and in NB; 5. Programmed Cell Death (PCD; Apoptosis) in Development of NB; 6. The Role of Epithelial to Mesenchymal Transition (EMT) in Development and Metastasis; 7. The Role of miRNA in Development and NB; 8. Other Important Genes in NB; 9. Clinical Treatment Overview; 10. Conclusion; Acknowledgments; References; Chapter 5: RB1, Development, and Cancer; 1. Introduction; 2. The Pocket Proteins; 3. The pRb/E2F Cell Cycle Switch
  • 4. Evolutionary Conservation of the Switch5. Variations on the Switch; 6. Rb1 Function Beyond Transcription; 7. Rb1, Stem Cells, and the Cell of Tumor Origin; 8. Rb1 and Tumor Progression; 9. Summary; Acknowledgments; References; Chapter 6: Genetic Alterations Targeting Lymphoid Development in Acute Lymphoblastic Leukemia; 1. Introduction; 2. Genetics of ALL; 3. Lymphoid Development; 4. Genome-Wide Profiling of Genetic Alterations in Cancer; 5. Genome-Wide Profiling of Genetic Alterations in ALL; 6. Genetic Alterations Targeting Lymphoid Development in B-ALL
  • 7. IKZF1 Alterations in BCR-ABL1 Positive ALL
Dimensions
unknown
Edition
1st ed.
Extent
1 online resource (397 p.)
Form of item
online
Isbn
9780123809179
Media category
computer
Media type code
c
Specific material designation
remote
System control number
  • (CKB)3390000000006044
  • (EBL)680861
  • (OCoLC)741491867
  • (SSID)ssj0000521346
  • (PQKBManifestationID)12205186
  • (PQKBTitleCode)TC0000521346
  • (PQKBWorkID)10518384
  • (PQKB)10518714
  • (MiAaPQ)EBC680861
  • (EXLCZ)993390000000006044

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