The Resource Celecoxib versus non-COX-2 selective non-steroidal anti-inflammatory drugs : a review of the clinical effectiveness, safety, and cost effectiveness, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Celecoxib versus non-COX-2 selective non-steroidal anti-inflammatory drugs : a review of the clinical effectiveness, safety, and cost effectiveness, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Label
Celecoxib versus non-COX-2 selective non-steroidal anti-inflammatory drugs : a review of the clinical effectiveness, safety, and cost effectiveness
Title
Celecoxib versus non-COX-2 selective non-steroidal anti-inflammatory drugs
Title remainder
a review of the clinical effectiveness, safety, and cost effectiveness
Statement of responsibility
[prepared by Canadian Agency for Drugs and Technologies in Health]
Contributor
Subject
Genre
Language
eng
Summary
Osteoarthritis (OA) is a chronic condition involving degeneration of cartilage within the joints. It is the most common form of arthritis and is associated with pain, substantial disability and poor quality of life.1 Rheumatoid arthritis (RA) is a systemic auto-immune disorder, involving persistent joint inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in controlling the symptoms of arthritis including OA and RA, lower back pain and soft tissue pain, by blocking cyclooxygenase (COX) enzymes. Two COX isoenzymes, COX-1 and COX-2, have important roles in the effects of NSAIDs. COX-1 mediates the mucosal protection of the gastrointestinal (GI) mucosa, while COX-2 is found throughout the body, including joint and muscle and mediates effects on pain and inflammation. By blocking COX-2, NSAIDs reduce pain from different etiologies, such as arthritis, lower back pain, minor injuries and soft-tissue rheumatism.1 NSAIDs that block both COX-1 and COX-2 enzymes are called non-COX-2 selective NSAIDs (nsNSAIDs) and can cause GI bleeding. NSAIDs that target only the COX-2 enzyme, such as celecoxib, are called COX-2 selective NSAIDs and are deemed safer with regards to GI bleeding than nsNSAIDs. Studies found, however, that they may increase the risk of cardiovascular (CV) adverse events. Celecoxib is a commonly used COX-2 selective inhibitor and is indicated for the relief of symptoms associated with OA, RA and ankylosing spondylitis (AS). The purpose of this report is to review the evidence regarding the use of celecoxib in adult patients with OA, RA or other diseases that require pain management. Its clinical effectiveness, safety, and cost-effectiveness are compared with those of nsNSAIDs
Member of
Cataloging source
CaBNVSL
Dewey number
616.7/23061
Illustrations
illustrations
Index
no index present
LC call number
RC933
LC item number
.C445 2011eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WE 344
NLM item number
C445 2011eb
http://library.link/vocab/relatedWorkOrContributorName
  • Canadian Agency for Drugs and Technologies in Health
  • Canadian Electronic Library (Firm)
Series statement
Rapid response report, summary with critical appraisal
http://library.link/vocab/subjectName
  • Celecoxib
  • Nonsteroidal anti-inflammatory agents
  • Pain
  • Osteoarthritis
  • Osteoarthritis
  • Cyclooxygenase 2 Inhibitors
  • Anti-Inflammatory Agents, Non-Steroidal
Label
Celecoxib versus non-COX-2 selective non-steroidal anti-inflammatory drugs : a review of the clinical effectiveness, safety, and cost effectiveness, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/230838
Instantiates
Publication
Note
  • "07 December 2011"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 10-11)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (20 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
230838
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00550976
  • (OCoLC)780140531
  • (CaOOCEL)230838
System details
Mode of access: World Wide Web
Label
Celecoxib versus non-COX-2 selective non-steroidal anti-inflammatory drugs : a review of the clinical effectiveness, safety, and cost effectiveness, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/230838
Publication
Note
  • "07 December 2011"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 10-11)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (20 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
230838
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00550976
  • (OCoLC)780140531
  • (CaOOCEL)230838
System details
Mode of access: World Wide Web

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