The Resource Corneal cross-linking with riboflavin for keratoconus : a review of the clinical and cost-effectiveness, [prepared by Canadian Agency for Drugs and Technologies in Health]

Corneal cross-linking with riboflavin for keratoconus : a review of the clinical and cost-effectiveness, [prepared by Canadian Agency for Drugs and Technologies in Health]

Label
Corneal cross-linking with riboflavin for keratoconus : a review of the clinical and cost-effectiveness
Title
Corneal cross-linking with riboflavin for keratoconus
Title remainder
a review of the clinical and cost-effectiveness
Statement of responsibility
[prepared by Canadian Agency for Drugs and Technologies in Health]
Contributor
Distributor
Publisher
Subject
Genre
Language
eng
Summary
Keratoconus (KC) is a degenerative disorder of the eye in which cornea becomes progressively thinner and bows outward into a more conical shape than its normal gradual curve. KC affects approximately 0.05% of the global population. Patients with KC often experience eye irritation, headaches, light halos, light sensitivity, worsening myopia, and impaired quality of life. KC is usually diagnosed in the adolescent period. Various treatment options for KC include simple correction with glasses, soft or rigid gas permeable contact lenses, surgical implantation of intrastromal corneal ring segments (Intacs), and corneal transplant. In addition, corneal-crosslinking with riboflavin and ultraviolet A (CXL) is increasingly considered as a method for managing KC. The treatment objective for CXL is to stabilize the underlying disease process by strengthening the stromal collagen network in order to delay or defer the need for corneal transplant. In the process of CXL, riboflavin (vitamin B2) works as a photo-mediator to increase the absorption of ultraviolet A light into the corneal stroma. The ultraviolet A (UVA: 370 nm) light increases the degree of molecular bonds of the extracellular matrix of the cornea. Therefore, CXL slows or even stops the progression of KC by increasing the strength and rigidity of the cornea. CXL can be performed with or without removing corneal epithelium. Common reported side-effects of CXL are blurry vision, lacrimation and the sensation of a foreign body for approximately 24 to 48 hours. Serious side effects include corneal haze and keratitis. CXL is only indicated for patients with corneas greater than 400 mcm thick. Corneal cross-linking with riboflavin -- UVA for keratoconus has been increasingly used in some Canadian jurisdictions. However it is currently not covered by any Canadian jurisdiction. Demand for CXL as the standard of care for keratoconus is increasing in some Canadian jurisdictions, although the long-term effectiveness and CXL's impact on the need for corneal transplant is unk
Member of
Cataloging source
CaBNVSL
Dewey number
617.719
Illustrations
illustrations
Index
no index present
LC call number
RE339
LC item number
.C673 2013eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WW 220
NLM item number
C673 2013eb
http://library.link/vocab/relatedWorkOrContributorName
  • Canadian Agency for Drugs and Technologies in Health
  • Canadian Electronic Library (Firm)
Series statement
Rapid response report, summary with critical appraisal
http://library.link/vocab/subjectName
  • Keratoconus
  • Vitamin B2
  • Collagen
  • Keratoconus
  • Keratoconus
  • Collagen
  • Photochemotherapy
  • Riboflavin
  • Cost-Benefit Analysis
Label
Corneal cross-linking with riboflavin for keratoconus : a review of the clinical and cost-effectiveness, [prepared by Canadian Agency for Drugs and Technologies in Health]
Link
http://www.deslibris.ca/ID/240020
Instantiates
Publication
Distribution
Note
  • "18 September 2013"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 8-9)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type MARC source
rdacontent
Dimensions
unknown
Extent
1 electronic text (16 pages)
Form of item
online
Media category
electronic
Media MARC source
isbdmedia
Other physical details
tables.
Publisher number
240020
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00557678
  • (OCoLC)865475908
  • (CaOOCEL)240020
System details
Mode of access: World Wide Web
Label
Corneal cross-linking with riboflavin for keratoconus : a review of the clinical and cost-effectiveness, [prepared by Canadian Agency for Drugs and Technologies in Health]
Link
http://www.deslibris.ca/ID/240020
Publication
Distribution
Note
  • "18 September 2013"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 8-9)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type MARC source
rdacontent
Dimensions
unknown
Extent
1 electronic text (16 pages)
Form of item
online
Media category
electronic
Media MARC source
isbdmedia
Other physical details
tables.
Publisher number
240020
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00557678
  • (OCoLC)865475908
  • (CaOOCEL)240020
System details
Mode of access: World Wide Web

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