The Resource Denosumab and zoledronic acid for patients with postmenopausal osteoporosis : a review of the clinical effectiveness, safety, cost effectiveness, and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Denosumab and zoledronic acid for patients with postmenopausal osteoporosis : a review of the clinical effectiveness, safety, cost effectiveness, and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Label
Denosumab and zoledronic acid for patients with postmenopausal osteoporosis : a review of the clinical effectiveness, safety, cost effectiveness, and guidelines
Title
Denosumab and zoledronic acid for patients with postmenopausal osteoporosis
Title remainder
a review of the clinical effectiveness, safety, cost effectiveness, and guidelines
Statement of responsibility
[prepared by Canadian Agency for Drugs and Technologies in Health]
Contributor
Subject
Genre
Language
eng
Summary
Osteoporosis is characterized by low bone mineral density (BMD), deterioration of bone microarchitecture, and a consequent increase in bone fragility and risk of fracture.1 Osteoporosis is most prevalent in postmenopausal women over 50 as estrogen levels decline. BMD is determined by the delicate balance of bone resorption (osteoclast activity) and bone formation (osteoblast activity), with osteoporosis occurring when bone resorption exceeds bone formation. There are several therapies available for the prevention and management of postmenopausal osteoporosis. Nitrogen-containing bisphosphonates are highly potent inhibitors of osteoclastic bone resorption and have proven to be effective at reducing vertebral fracture risk. Bisphosphonates such as alendronate and risedronate have been used for treatment of postmenopausal osteoporosis for many years and are taken orally with a daily dosage regimen. Zoledronic acid (Aclasta) is a newer bisphosphonate administered intravenously once-yearly. Recent advancements in the field of bone biology have led to the development of a new class of postmenopausal osteoporosis therapy. Denosumab (Prolia) is a human recombinant monoclonal antibody that binds to RANKL, a protein that acts as an essential mediator of osteoclast formation, thereby inhibiting osteoclast formation, function, and survival. Denosumab is administered subcutaneously at six-month intervals. Due to the complex dosing regimen of oral bisphosphonates, compliance rates may be low, making therapies such as zoledronic acid and denosumab attractive treatment options. Both denosumab and zoledronic acid have been approved for listing within Canada's publicly funded drug plans for women aged 75 years or older who have had a previous fragility fracture and a BMD T-score ? -2.5, or more than 2.5 standard deviations below the mean peak bone mass.11,12 In addition, the patient must be contraindicated for bisphosphonate therapy due to hypersensitivity or abnormality of the esophagus. Despite these criteria, there is limited e
Member of
Cataloging source
CaBNVSL
Dewey number
616.716
Illustrations
illustrations
Index
no index present
LC call number
RC931.O73
LC item number
D458 2012eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WE 250
NLM item number
D458 2012eb
http://library.link/vocab/relatedWorkOrContributorName
  • Canadian Agency for Drugs and Technologies in Health
  • Canadian Electronic Library (Firm)
Series statement
Rapid response report, summary with critical appraisal
http://library.link/vocab/subjectName
  • Osteoporosis in women
  • Osteoporosis drugs
  • Diphosphonates
  • Osteoporosis, Postmenopausal
  • Antibodies, Monoclonal
  • Diphosphonates
  • Imidazoles
  • Bone Density Conservation Agents
Label
Denosumab and zoledronic acid for patients with postmenopausal osteoporosis : a review of the clinical effectiveness, safety, cost effectiveness, and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/233783
Instantiates
Publication
Note
  • "29 June 2012"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 9-11)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (20 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
233783
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00553093
  • (OCoLC)812915821
  • (CaOOCEL)233783
System details
Mode of access: World Wide Web
Label
Denosumab and zoledronic acid for patients with postmenopausal osteoporosis : a review of the clinical effectiveness, safety, cost effectiveness, and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/233783
Publication
Note
  • "29 June 2012"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 9-11)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (20 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
233783
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00553093
  • (OCoLC)812915821
  • (CaOOCEL)233783
System details
Mode of access: World Wide Web

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