The Resource Handbook of Immunological Properties of Engineered Nanomaterials, (electronic resource)

Handbook of Immunological Properties of Engineered Nanomaterials, (electronic resource)

Label
Handbook of Immunological Properties of Engineered Nanomaterials
Title
Handbook of Immunological Properties of Engineered Nanomaterials
Title variation
  • Frontiers In Nanobiomedical Research vol. 1
  • Frontiers In Nano Biomedical Research vol. 1
Creator
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilizat
Cataloging source
AU-PeEL
http://library.link/vocab/creatorName
Dobrovolskaia, Marina A
Dewey number
616.079028
Language note
English
LC call number
TA418.9.P6 .D384 2012
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
McNeil, Scott E
Series statement
Frontiers in nanobiomedical research Handbook of immunological properties of engineered nanomaterials
http://library.link/vocab/subjectName
  • Diffusion
  • Immunotoxicology
  • Nanostructured materials
  • Nanostructured materials
  • Nanostructured materials
  • Nanotechnology
  • Biomedical materials
  • Immune System Phenomena
  • Manufactured Materials
  • Technology, Industry, and Agriculture
  • Immune System Processes
  • Nanostructures
  • Health & Biological Sciences
  • Biomedical Engineering
Label
Handbook of Immunological Properties of Engineered Nanomaterials, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
  • Contents; Preface; List of Contributors; Chapter 1 Immunological Properties of Engineered Nanomaterials: An Introduction Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. Interaction with Blood Components; 2.1. Hemolysis; 2.2. Coagulation; 2.3. Complement activation; 3. Nanoparticle Uptake by Phagocytic Cells; 4. Immunogenicity; 4.1. Inflammation; 4.2. Antigenicity; 4.3. Adjuvant properties; 5. Immunosuppression; 6. Designing Immunotoxicity Studies; 7. Future Directions; References
  • Chapter 2 Importance of Physicochemical Characterization Prior to Immunological Studies Jeffrey D. Clogston and Anil K. Patri1. Introduction; 2. Key Parameters that Influence Nanomaterial Immunological Properties; 3. Instrumentation for Physicochemical Characterization; 4. Methodologies for Nanomaterial Separation; 5. A Closer Look; 5.1. Dynamic light scattering; 5.1.1. Additional considerations for DLS measurements; 5.2. Zeta potential; 6. Summary; References; Chapter 3 Impact of Nanoparticle Sterilization on Analytical Characterization Nanda Subbarao; 1. Introduction
  • 2. Why Is Sterilization a Challenge for Nanotherapeutics?3. Previous Studies Reviewing the Effects of Various Sterilization Procedures on Nanomaterials; 4. Available Methods for Sterilization; 4.1. Autoclaving; 4.1.1. Impact on NT analytics; 4.2. Filtration; 4.2.1. Impact on NT analytics; 4.3. Gamma irradiation; 4.3.1. Gamma irradiation of SLNs; 4.3.2. Gamma irradiation and liposomes; 4.3.3. Mitigating the effects of gamma irradiation; 4.3.4. Gamma irradiation remains a method of choice for NTs; 4.3.5. Impact on NT analytics; 4.4. Gaseous ethylene oxide; 4.4.1. Impact on NT analytics
  • 4.5. High hydrostatic pressure sterilization4.6. Formaldehyde; 5. Comparison of Different Methods for Sterilization; 6. Impact on Nanotherapeutic Analytics; 7. Conclusions; References; Chapter 4 Endotoxin and Engineered Nanomaterials Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. What Endotoxin Is and Why It Is Important to Study in Nanoformulations; 3. Methods Used for Endotoxin Detection and Quantification; 3.1. Traditional methods; 3.2. Alternative methods; 3.2.1. Gel-staining-based methods; 3.2.2. Ligand binding-based methods; 3.2.3. Mass spectrometry-based methods
  • 3.2.4. Macrophage activation test4. Estimating Endotoxin in Nanoformulations; 4.1. Nanoparticle interference with traditional methods; 4.2. Evaluation of interference; 4.3. How to choose an appropriate LAL format; 4.4. Application of non-traditional methods; 4.4.1. Gel-based assay; 4.4.2. Western blot-based assay; 5. Use of Traditional Endotoxin-Neutralizing Reagents in Nanoparticle Research; 5.1. Case study 1; 5.2. Case study 2; 6. Minimizing Contamination and Interference; 7. Purification and Depyrogenation of Nanoformulations; 8. Conclusions and Future Directions; References
  • Chapter 5 Surface Adsorbates on Nanomaterials and Their Possible Roles in Host Inflammatory and Toxicological Processing Clinton F. Jones, David G. Castner, and David W. Grainger
Dimensions
unknown
Extent
1 online resource (721 p.)
Form of item
electronic
Isbn
9789814390255
Media category
computer
Media type code
  • c
Specific material designation
remote
System control number
  • (CKB)2550000001006232
  • (EBL)1126833
  • (OCoLC)828792689
  • (SSID)ssj0000819378
  • (PQKBManifestationID)12341029
  • (PQKBTitleCode)TC0000819378
  • (PQKBWorkID)10844892
  • (PQKB)11145176
Label
Handbook of Immunological Properties of Engineered Nanomaterials, (electronic resource)
Publication
Note
Description based upon print version of record
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
  • Contents; Preface; List of Contributors; Chapter 1 Immunological Properties of Engineered Nanomaterials: An Introduction Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. Interaction with Blood Components; 2.1. Hemolysis; 2.2. Coagulation; 2.3. Complement activation; 3. Nanoparticle Uptake by Phagocytic Cells; 4. Immunogenicity; 4.1. Inflammation; 4.2. Antigenicity; 4.3. Adjuvant properties; 5. Immunosuppression; 6. Designing Immunotoxicity Studies; 7. Future Directions; References
  • Chapter 2 Importance of Physicochemical Characterization Prior to Immunological Studies Jeffrey D. Clogston and Anil K. Patri1. Introduction; 2. Key Parameters that Influence Nanomaterial Immunological Properties; 3. Instrumentation for Physicochemical Characterization; 4. Methodologies for Nanomaterial Separation; 5. A Closer Look; 5.1. Dynamic light scattering; 5.1.1. Additional considerations for DLS measurements; 5.2. Zeta potential; 6. Summary; References; Chapter 3 Impact of Nanoparticle Sterilization on Analytical Characterization Nanda Subbarao; 1. Introduction
  • 2. Why Is Sterilization a Challenge for Nanotherapeutics?3. Previous Studies Reviewing the Effects of Various Sterilization Procedures on Nanomaterials; 4. Available Methods for Sterilization; 4.1. Autoclaving; 4.1.1. Impact on NT analytics; 4.2. Filtration; 4.2.1. Impact on NT analytics; 4.3. Gamma irradiation; 4.3.1. Gamma irradiation of SLNs; 4.3.2. Gamma irradiation and liposomes; 4.3.3. Mitigating the effects of gamma irradiation; 4.3.4. Gamma irradiation remains a method of choice for NTs; 4.3.5. Impact on NT analytics; 4.4. Gaseous ethylene oxide; 4.4.1. Impact on NT analytics
  • 4.5. High hydrostatic pressure sterilization4.6. Formaldehyde; 5. Comparison of Different Methods for Sterilization; 6. Impact on Nanotherapeutic Analytics; 7. Conclusions; References; Chapter 4 Endotoxin and Engineered Nanomaterials Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. What Endotoxin Is and Why It Is Important to Study in Nanoformulations; 3. Methods Used for Endotoxin Detection and Quantification; 3.1. Traditional methods; 3.2. Alternative methods; 3.2.1. Gel-staining-based methods; 3.2.2. Ligand binding-based methods; 3.2.3. Mass spectrometry-based methods
  • 3.2.4. Macrophage activation test4. Estimating Endotoxin in Nanoformulations; 4.1. Nanoparticle interference with traditional methods; 4.2. Evaluation of interference; 4.3. How to choose an appropriate LAL format; 4.4. Application of non-traditional methods; 4.4.1. Gel-based assay; 4.4.2. Western blot-based assay; 5. Use of Traditional Endotoxin-Neutralizing Reagents in Nanoparticle Research; 5.1. Case study 1; 5.2. Case study 2; 6. Minimizing Contamination and Interference; 7. Purification and Depyrogenation of Nanoformulations; 8. Conclusions and Future Directions; References
  • Chapter 5 Surface Adsorbates on Nanomaterials and Their Possible Roles in Host Inflammatory and Toxicological Processing Clinton F. Jones, David G. Castner, and David W. Grainger
Dimensions
unknown
Extent
1 online resource (721 p.)
Form of item
electronic
Isbn
9789814390255
Media category
computer
Media type code
  • c
Specific material designation
remote
System control number
  • (CKB)2550000001006232
  • (EBL)1126833
  • (OCoLC)828792689
  • (SSID)ssj0000819378
  • (PQKBManifestationID)12341029
  • (PQKBTitleCode)TC0000819378
  • (PQKBWorkID)10844892
  • (PQKB)11145176

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