The Resource Handbook of epigenetics : the new molecular and medical genetics, Trygve Tollefsbol, (electronic resource)

Handbook of epigenetics : the new molecular and medical genetics, Trygve Tollefsbol, (electronic resource)

Label
Handbook of epigenetics : the new molecular and medical genetics
Title
Handbook of epigenetics
Title remainder
the new molecular and medical genetics
Statement of responsibility
Trygve Tollefsbol
Creator
Subject
Genre
Language
  • eng
  • eng
Summary
Epigenetics is considered by many to be the ""new genetics"" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and impr
Cataloging source
MiAaPQ
http://library.link/vocab/creatorName
Tollefsbol, Trygve O
Dewey number
572.865
Illustrations
  • illustrations
  • plates
Index
index present
Language note
English
LC call number
QH450
LC item number
.H36 2010
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/subjectName
  • Epigenesis
  • Genetic regulation
Label
Handbook of epigenetics : the new molecular and medical genetics, Trygve Tollefsbol, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
  • FRONT COVER; HANDBOOK OF EPIGENETICS; COPYRIGHT PAGE; CONTENTS; CONTRIBUTORS; PREFACE; 1 Epigenetics: The New Science of Genetics; INTRODUCTION; THE BASICS OF DNA METHYLATION AND HISTONE MODIFICATIONS; ADDITIONAL EPIGENETIC PROCESSES; EPIGENETIC TECHNOLOGY; MODEL ORGANISMS OF EPIGENETICS; METABOLISM AND EPIGENETICS; FUNCTIONS OF EPIGENETICS; EVOLUTIONARY EPIGENETICS; EPIGENETIC EPIDEMIOLOGY; EPIGENETICS AND HUMAN DISEASES; EPIGENETIC THERAPY; CONCLUSION; References; I: Molecular Mechanisms of Epigenetics; 2 Mechanisms of DNA Methylation, Methyl-CpG Recognition, and Demethylation in Mammals
  • INTRODUCTIONMAMMALIAN DNA MTases; Dnmt3L IS A REGULATORY FACTOR FOR DE NOVO DNA METHYLATION; DIMERIC Dnmt3a SUGGESTS DE NOVO DNA METHYLATION DEPENDS ON CpG SPACING; Dnmt3L CONNECTS UNMETHYLATED HISTONE H3 LYSINE 4 TO DE NOVO DNA METHYLATION; A STRUCTURAL FRAGMENT OF Dnmt1; THE SRA DOMAIN OF UHRF1 FLIPS 5-METHYLCYTOSINE OUT OF THE DNA HELIX; BASE FLIPPING MECHANISM; UHRF1-HISTONE INTERACTIONS; REPLICATION-COUPLED CROSSTALK BETWEEN DNA METHYLATION AND HISTONE MODIFICATIONS; DNA DEMETHYLATION VIA HYDROXYLATION?; DNA DEMETHYLATION VIA GLYCOSYLATION?
  • Dnmt2, AN ENIGMATIC DNA METHYLTRANSFERASE HOMOLOGCONCLUSION AND PERSPECTIVES; ACKNOWLEDGEMENTS; References; 3 Mechanisms of Histone Modifications; INTRODUCTION; HISTONE MODIFICATIONS; SUMMARY AND PERSPECTIVES; References; II: Additional Epigenetic Processes; 4 The Epigenetics of Non-coding RNA; INTRODUCTION; SHORT ncRNAs AND EPIGENETICS; LONG ncRNAs AND EPIGENETICS; CONCLUSIONS; ACKNOWLEDGEMENTS; References; 5 Prions and Prion-like Phenomena in Epigenetic Inheritance; STRUCTURAL HEREDITY; MIXED HEREDITY: A PRION THAT PROPAGATES BY COVALENT AUTO-ACTIVATION; REGULATORY INHERITANCE; CONCLUSION
  • References6 Chromosomal Position Effects and Gene Variegation: Impact in Pathologies; INTRODUCTION; CPE AND TPE, LESSONS FROM MODEL ORGANISMS; SETTING THE FRONTIERS OF CHROMATIN DOMAINS; CPE AND GENE TRANSFER; CHROMOSOMAL POSITION EFFECT IN HUMAN PATHOLOGIES; DISORDERS OF UNSTABLE REPEAT EXPANSIONS; COPY NUMBER VARIANTS: A NEW CHALLENGE IN THE DECIPHERING OF CPE; TELOMERIC POSITION EFFECT IN HUMAN PATHOLOGIES; POSITION EFFECTS AND AGING; CONCLUSIONS; ACKNOWLEDGEMENTS; References; 7 Polycomb Mechanisms and Epigenetic Control of Gene Activity; INTRODUCTION; THE HARDWARE
  • THE POLYCOMB RESPONSE ELEMENTRECRUITERS; THE H3K27 METHYL MARK; RECRUITMENT BY H3K27me3; HOW DO PcG MECHANISMS REPRESS?; EPIGENETIC MAINTENANCE OR CELLULAR MEMORY; MAINTENANCE OF THE NON-REPRESSED STATE; PcG BINDING DOES NOT NECESSARILY RESULT IN SILENCING; THE BIVALENT STATE; DIFFERENTIATION; CONCLUSIONS; References; III: Epigenetic Technology; 8 Analysis of Gene-specific DNA Methylation; INTRODUCTION; PRINCIPLES OF DNA METHYLATION ANALYSIS; CHARACTERISTICS OF INDIVIDUAL TECHNIQUES; TIPS FOR BISULFITE SEQUENCING; TIPS FOR MSP AND QUANTITATIVE MSP; EPILOGUE; References
  • 9 Methods for Assessing Genome-wide DNA Methylation
Dimensions
unknown
Extent
1 online resource (639 p.)
Form of item
online
Isbn
9781282878990
Media category
computer
Media type code
  • c
Specific material designation
remote
System control number
  • (CKB)2560000000015239
  • (EBL)610531
  • (OCoLC)683414184
  • (SSID)ssj0000437445
  • (PQKBManifestationID)12140803
  • (PQKBTitleCode)TC0000437445
  • (PQKBWorkID)10432758
  • (PQKB)11131410
  • (MiAaPQ)EBC610531
  • (EXLCZ)992560000000015239
Label
Handbook of epigenetics : the new molecular and medical genetics, Trygve Tollefsbol, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
  • FRONT COVER; HANDBOOK OF EPIGENETICS; COPYRIGHT PAGE; CONTENTS; CONTRIBUTORS; PREFACE; 1 Epigenetics: The New Science of Genetics; INTRODUCTION; THE BASICS OF DNA METHYLATION AND HISTONE MODIFICATIONS; ADDITIONAL EPIGENETIC PROCESSES; EPIGENETIC TECHNOLOGY; MODEL ORGANISMS OF EPIGENETICS; METABOLISM AND EPIGENETICS; FUNCTIONS OF EPIGENETICS; EVOLUTIONARY EPIGENETICS; EPIGENETIC EPIDEMIOLOGY; EPIGENETICS AND HUMAN DISEASES; EPIGENETIC THERAPY; CONCLUSION; References; I: Molecular Mechanisms of Epigenetics; 2 Mechanisms of DNA Methylation, Methyl-CpG Recognition, and Demethylation in Mammals
  • INTRODUCTIONMAMMALIAN DNA MTases; Dnmt3L IS A REGULATORY FACTOR FOR DE NOVO DNA METHYLATION; DIMERIC Dnmt3a SUGGESTS DE NOVO DNA METHYLATION DEPENDS ON CpG SPACING; Dnmt3L CONNECTS UNMETHYLATED HISTONE H3 LYSINE 4 TO DE NOVO DNA METHYLATION; A STRUCTURAL FRAGMENT OF Dnmt1; THE SRA DOMAIN OF UHRF1 FLIPS 5-METHYLCYTOSINE OUT OF THE DNA HELIX; BASE FLIPPING MECHANISM; UHRF1-HISTONE INTERACTIONS; REPLICATION-COUPLED CROSSTALK BETWEEN DNA METHYLATION AND HISTONE MODIFICATIONS; DNA DEMETHYLATION VIA HYDROXYLATION?; DNA DEMETHYLATION VIA GLYCOSYLATION?
  • Dnmt2, AN ENIGMATIC DNA METHYLTRANSFERASE HOMOLOGCONCLUSION AND PERSPECTIVES; ACKNOWLEDGEMENTS; References; 3 Mechanisms of Histone Modifications; INTRODUCTION; HISTONE MODIFICATIONS; SUMMARY AND PERSPECTIVES; References; II: Additional Epigenetic Processes; 4 The Epigenetics of Non-coding RNA; INTRODUCTION; SHORT ncRNAs AND EPIGENETICS; LONG ncRNAs AND EPIGENETICS; CONCLUSIONS; ACKNOWLEDGEMENTS; References; 5 Prions and Prion-like Phenomena in Epigenetic Inheritance; STRUCTURAL HEREDITY; MIXED HEREDITY: A PRION THAT PROPAGATES BY COVALENT AUTO-ACTIVATION; REGULATORY INHERITANCE; CONCLUSION
  • References6 Chromosomal Position Effects and Gene Variegation: Impact in Pathologies; INTRODUCTION; CPE AND TPE, LESSONS FROM MODEL ORGANISMS; SETTING THE FRONTIERS OF CHROMATIN DOMAINS; CPE AND GENE TRANSFER; CHROMOSOMAL POSITION EFFECT IN HUMAN PATHOLOGIES; DISORDERS OF UNSTABLE REPEAT EXPANSIONS; COPY NUMBER VARIANTS: A NEW CHALLENGE IN THE DECIPHERING OF CPE; TELOMERIC POSITION EFFECT IN HUMAN PATHOLOGIES; POSITION EFFECTS AND AGING; CONCLUSIONS; ACKNOWLEDGEMENTS; References; 7 Polycomb Mechanisms and Epigenetic Control of Gene Activity; INTRODUCTION; THE HARDWARE
  • THE POLYCOMB RESPONSE ELEMENTRECRUITERS; THE H3K27 METHYL MARK; RECRUITMENT BY H3K27me3; HOW DO PcG MECHANISMS REPRESS?; EPIGENETIC MAINTENANCE OR CELLULAR MEMORY; MAINTENANCE OF THE NON-REPRESSED STATE; PcG BINDING DOES NOT NECESSARILY RESULT IN SILENCING; THE BIVALENT STATE; DIFFERENTIATION; CONCLUSIONS; References; III: Epigenetic Technology; 8 Analysis of Gene-specific DNA Methylation; INTRODUCTION; PRINCIPLES OF DNA METHYLATION ANALYSIS; CHARACTERISTICS OF INDIVIDUAL TECHNIQUES; TIPS FOR BISULFITE SEQUENCING; TIPS FOR MSP AND QUANTITATIVE MSP; EPILOGUE; References
  • 9 Methods for Assessing Genome-wide DNA Methylation
Dimensions
unknown
Extent
1 online resource (639 p.)
Form of item
online
Isbn
9781282878990
Media category
computer
Media type code
  • c
Specific material designation
remote
System control number
  • (CKB)2560000000015239
  • (EBL)610531
  • (OCoLC)683414184
  • (SSID)ssj0000437445
  • (PQKBManifestationID)12140803
  • (PQKBTitleCode)TC0000437445
  • (PQKBWorkID)10432758
  • (PQKB)11131410
  • (MiAaPQ)EBC610531
  • (EXLCZ)992560000000015239

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