The Resource Heme biology : the secret life of heme in regulating diverse biological processes, editor, Li Zhang, (electronic resource)

Heme biology : the secret life of heme in regulating diverse biological processes, editor, Li Zhang, (electronic resource)

Label
Heme biology : the secret life of heme in regulating diverse biological processes
Title
Heme biology
Title remainder
the secret life of heme in regulating diverse biological processes
Statement of responsibility
editor, Li Zhang
Contributor
Subject
Genre
Language
  • eng
  • eng
Summary
This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction to the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It then proceeds to describe the versatile roles of heme in controlling diverse molecular and cellular processes germane to human life and disease processes. Finally, an up-to-date review of human diseases associated with heme synthesis and application of heme synthesis in photodynamic therapy in cancer
Cataloging source
MiAaPQ
Dewey number
  • 572.8
  • 612.111
Illustrations
illustrations
Index
index present
Language note
English
LC call number
QP671.H45
LC item number
H46 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Zhang, Li
http://library.link/vocab/subjectName
Heme
Label
Heme biology : the secret life of heme in regulating diverse biological processes, editor, Li Zhang, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Preface; CONTENTS; List of Contributors; Chapter 1 Introduction Li Zhang; Overview; References; Chapter 2 Heme Biosynthesis and Degradation: What Happens when it goes Haywire? Li Zhang and Rebekah Sessoms; Overview; Heme is synthesized by the actions of eight enzymes in humans; Heme biosynthesis is regulated according to the needs for heme in human cells; Defective heme biosynthesis causes serious diseases in humans; Heme is degraded continuously in the human body; Defects in heme degradation can cause serious diseases; References
  • Chapter 3 Heme: An Ingenious Regulator of Gene Transcription Li ZhangOverview; Heme can control the activity of diverse transcriptional regulators; Heme serves as a secondary messenger of oxygen in yeast; Heme can control the expression of a high number of genes in yeast; The heme activator protein Hap1 is a key regulator of gene transcription in response to fluctuations in oxygen and heme levels; Heme regulation of Hap1 transcription-activating activity requires the proper functioning of Hsp90 and Hsp70 molecular chaperones
  • Bach1: A heme-dependent transcriptional regulator in mammalian cellsBach1, like Hap1, binds to heme via HRMs; Heme affects Bach1 at three levels; Perspectives; References; Chapter 4 Heme-Regulated eIF2α Kinase in Translation and Erythropoiesis Jane-Jane Chen and Rajasekhar NVS Suragani; Overview; Introduction; HRI is responsible for heme-regulated translation in erythroid precursors; Phosphorylation of eIF2α under diverse cellular stresses by the family of eIF2α kinases; Activation of HRI by autophosphorylation; Inhibition of HRI activity by heme
  • Two distinct heme-binding domains in the cooperation of heme-regulation of HRITissue expression and phylogenetic conservation of HRI; Coordination of heme and globin synthesis by HRI; Regulation of erythroid differentiation by HRI; Integrated stress response of eIF2αP signaling; Concluding remarks; Acknowledgement; References; Chapter 5 Role of Heme in Brain Functions: Dr. Jekyll or Mr. Hyde? Tatyana Chernova and Andrew G. Smith; Overview; Heme synthesis and disturbances pertinent to neuronal cells; Contradictory roles of heme as a toxic and a physiological molecule
  • Neurotoxic effects of hemeAcute damage; Chronic damage; Neuroglobin, hemoglobin and their neuroprotective roles; Heme oxygenases and neurodegenerative diseases: Where does heme come from?; Emerging regulatory roles for heme in neurons; Neurotrophic effects of heme; Heme can act as a gas-sensing regulator of brain functions; Heme and brain aging: Role of heme for protection from drug-induced neurotoxicity; May sufficient availability of heme delay aging?; Deficiency of heme and Alzheimer's disease; Heme in circadian pathways; References; Chapter 6 Heme and microRNA Biogenesis Feng Guo
  • Overview
Dimensions
unknown
Extent
1 online resource (226 p.)
Form of item
online
Isbn
9781283433310
Media category
computer
Media type code
c
Specific material designation
remote
System control number
  • (CKB)2550000000079410
  • (EBL)840667
  • (OCoLC)858228382
  • (SSID)ssj0000573155
  • (PQKBManifestationID)12159806
  • (PQKBTitleCode)TC0000573155
  • (PQKBWorkID)10541199
  • (PQKB)10516224
  • (MiAaPQ)EBC840667
  • (EXLCZ)992550000000079410
Label
Heme biology : the secret life of heme in regulating diverse biological processes, editor, Li Zhang, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Preface; CONTENTS; List of Contributors; Chapter 1 Introduction Li Zhang; Overview; References; Chapter 2 Heme Biosynthesis and Degradation: What Happens when it goes Haywire? Li Zhang and Rebekah Sessoms; Overview; Heme is synthesized by the actions of eight enzymes in humans; Heme biosynthesis is regulated according to the needs for heme in human cells; Defective heme biosynthesis causes serious diseases in humans; Heme is degraded continuously in the human body; Defects in heme degradation can cause serious diseases; References
  • Chapter 3 Heme: An Ingenious Regulator of Gene Transcription Li ZhangOverview; Heme can control the activity of diverse transcriptional regulators; Heme serves as a secondary messenger of oxygen in yeast; Heme can control the expression of a high number of genes in yeast; The heme activator protein Hap1 is a key regulator of gene transcription in response to fluctuations in oxygen and heme levels; Heme regulation of Hap1 transcription-activating activity requires the proper functioning of Hsp90 and Hsp70 molecular chaperones
  • Bach1: A heme-dependent transcriptional regulator in mammalian cellsBach1, like Hap1, binds to heme via HRMs; Heme affects Bach1 at three levels; Perspectives; References; Chapter 4 Heme-Regulated eIF2α Kinase in Translation and Erythropoiesis Jane-Jane Chen and Rajasekhar NVS Suragani; Overview; Introduction; HRI is responsible for heme-regulated translation in erythroid precursors; Phosphorylation of eIF2α under diverse cellular stresses by the family of eIF2α kinases; Activation of HRI by autophosphorylation; Inhibition of HRI activity by heme
  • Two distinct heme-binding domains in the cooperation of heme-regulation of HRITissue expression and phylogenetic conservation of HRI; Coordination of heme and globin synthesis by HRI; Regulation of erythroid differentiation by HRI; Integrated stress response of eIF2αP signaling; Concluding remarks; Acknowledgement; References; Chapter 5 Role of Heme in Brain Functions: Dr. Jekyll or Mr. Hyde? Tatyana Chernova and Andrew G. Smith; Overview; Heme synthesis and disturbances pertinent to neuronal cells; Contradictory roles of heme as a toxic and a physiological molecule
  • Neurotoxic effects of hemeAcute damage; Chronic damage; Neuroglobin, hemoglobin and their neuroprotective roles; Heme oxygenases and neurodegenerative diseases: Where does heme come from?; Emerging regulatory roles for heme in neurons; Neurotrophic effects of heme; Heme can act as a gas-sensing regulator of brain functions; Heme and brain aging: Role of heme for protection from drug-induced neurotoxicity; May sufficient availability of heme delay aging?; Deficiency of heme and Alzheimer's disease; Heme in circadian pathways; References; Chapter 6 Heme and microRNA Biogenesis Feng Guo
  • Overview
Dimensions
unknown
Extent
1 online resource (226 p.)
Form of item
online
Isbn
9781283433310
Media category
computer
Media type code
c
Specific material designation
remote
System control number
  • (CKB)2550000000079410
  • (EBL)840667
  • (OCoLC)858228382
  • (SSID)ssj0000573155
  • (PQKBManifestationID)12159806
  • (PQKBTitleCode)TC0000573155
  • (PQKBWorkID)10541199
  • (PQKB)10516224
  • (MiAaPQ)EBC840667
  • (EXLCZ)992550000000079410

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