The Resource Hepatocytes : Methods and Protocols, edited by Patrick Maurel, (electronic resource)

Hepatocytes : Methods and Protocols, edited by Patrick Maurel, (electronic resource)

Label
Hepatocytes : Methods and Protocols
Title
Hepatocytes
Title remainder
Methods and Protocols
Statement of responsibility
edited by Patrick Maurel
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Hepatocytes account for approximately 80% of the liver mass and play a significant role in various aspects of liver physiopathology, exhibiting unrivaled complexity and diversity of functions. In Hepatocytes: Methods and Protocols, expert researchers provide the reader with methods, technical protocols, and review chapters focusing on selected areas of hepatocyte biology including isolation, culture, differentiation and stem cells, and hepatocyte use in clinical, basic, and applied research. With a specific emphasis on human hepatocytes, the volume presents chapters covering subjects including hepatocyte culture models, cryopreservation methods, differentiation assessment, liver ontogenesis, production of hepatocytes from stem cells, drug/xenobiotic metabolism, toxicity and transport, bile acid and blood coagulation factor production, infection by HBV and HCV, humanized animals, biortificial liver devices, hepatocyte transplantation. As a volume in the highly successful Methods in Molecular BiologyTM series, protocol chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Hepatocytes: Methods and Protocols will be useful to all those who are currently using or planning to use human, or animal, hepatocytes to investigate any aspect of liver physiopathology or who are interested in liver development or liver stem cells and liver biotherapy
Member of
Dewey number
612
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
FqnbPwAiulo
Image bit depth
0
Language note
English
LC call number
QP34-38
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
Maurel, Patrick.
Series statement
Methods in Molecular Biology,
Series volume
640
http://library.link/vocab/subjectName
  • Human physiology
  • Medicine
  • Clinical medicine
  • Human Physiology
  • Molecular Medicine
  • Hepatology
Label
Hepatocytes : Methods and Protocols, edited by Patrick Maurel, (electronic resource)
Instantiates
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
General Review on In Vitro Hepatocyte Models and Their Applications -- Human Foetal Hepatocytes: Isolation, Characterization, and Transplantation -- Isolation and Culture of Primary Hepatocytes from Resected Human Liver Tissue -- Optimisation of the Cryopreservation of Primary Hepatocytes -- Cryopreservation of Human Hepatocytes for Clinical Use -- Hepatocyte Differentiation -- Reversible Manipulation of Apoptosis Sensitivity in Cultured Hepatocytes by Matrix-Mediated Manipulation of Signaling Activities -- Markers and Signaling Factors for Stem Cell Differentiation to Hepatocytes: Lessons from Developmental Studies -- Hepatic Stem Cells -- Hepatic Stem Cells and Liver Development -- Generation of Hepatocytes from Human Embryonic Stem Cells -- Isolation and Culture of Adult Human Liver Progenitor Cells: In Vitro Differentiation to Hepatocyte-Like Cells -- The HepaRG Cell Line: Biological Properties and Relevance as a Tool for Cell Biology, Drug Metabolism, and Virology Studies -- Transdifferentiation of Pancreatic Cells to Hepatocytes -- Evaluation of Drug Metabolism, Drug–Drug Interactions, and In Vitro Hepatotoxicity with Cryopreserved Human Hepatocytes -- The Use of Human Hepatocytes to Investigate Drug Metabolism and CYP Enzyme Induction -- The Use of Hepatocytes to Investigate UDP-Glucuronosyltransferases and Sulfotransferases -- The Use of Hepatocytes to Investigate Drug Uptake Transporters -- Metabonomic Studies on Human Hepatocyte in Primary Culture -- The Application of HepRG Cells in Evaluation of Cytochrome P450 Induction Properties of Drug Compounds -- The Use of Hepatocytes to Investigate Drug Toxicity -- The Use of Human Hepatocytes to Investigate Bile Acid Synthesis -- Use of Human Hepatocytes to Investigate Blood Coagulation Factor -- Use of Human Hepatocytes to Investigate HCV Infection -- The Use of Hepatocytes to Investigate HDV Infection: The HDV/HepaRG Model -- Rodent Models of Liver Repopulation -- Chimeric Mice with Humanized Liver: Tools for the Study of Drug Metabolism, Excretion, and Toxicity -- Bioartificial Liver Support Systems -- Human Hepatocyte Transplantation
Dimensions
unknown
Edition
1st ed. 2010.
Extent
1 online resource (XX, 554 p.)
File format
multiple file formats
Form of item
online
Isbn
9781607616887
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-1-60761-688-7
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)2670000000065673
  • (SSID)ssj0000449606
  • (PQKBManifestationID)11318239
  • (PQKBTitleCode)TC0000449606
  • (PQKBWorkID)10429284
  • (PQKB)10273572
  • (DE-He213)978-1-60761-688-7
  • (EXLCZ)992670000000065673
Label
Hepatocytes : Methods and Protocols, edited by Patrick Maurel, (electronic resource)
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
General Review on In Vitro Hepatocyte Models and Their Applications -- Human Foetal Hepatocytes: Isolation, Characterization, and Transplantation -- Isolation and Culture of Primary Hepatocytes from Resected Human Liver Tissue -- Optimisation of the Cryopreservation of Primary Hepatocytes -- Cryopreservation of Human Hepatocytes for Clinical Use -- Hepatocyte Differentiation -- Reversible Manipulation of Apoptosis Sensitivity in Cultured Hepatocytes by Matrix-Mediated Manipulation of Signaling Activities -- Markers and Signaling Factors for Stem Cell Differentiation to Hepatocytes: Lessons from Developmental Studies -- Hepatic Stem Cells -- Hepatic Stem Cells and Liver Development -- Generation of Hepatocytes from Human Embryonic Stem Cells -- Isolation and Culture of Adult Human Liver Progenitor Cells: In Vitro Differentiation to Hepatocyte-Like Cells -- The HepaRG Cell Line: Biological Properties and Relevance as a Tool for Cell Biology, Drug Metabolism, and Virology Studies -- Transdifferentiation of Pancreatic Cells to Hepatocytes -- Evaluation of Drug Metabolism, Drug–Drug Interactions, and In Vitro Hepatotoxicity with Cryopreserved Human Hepatocytes -- The Use of Human Hepatocytes to Investigate Drug Metabolism and CYP Enzyme Induction -- The Use of Hepatocytes to Investigate UDP-Glucuronosyltransferases and Sulfotransferases -- The Use of Hepatocytes to Investigate Drug Uptake Transporters -- Metabonomic Studies on Human Hepatocyte in Primary Culture -- The Application of HepRG Cells in Evaluation of Cytochrome P450 Induction Properties of Drug Compounds -- The Use of Hepatocytes to Investigate Drug Toxicity -- The Use of Human Hepatocytes to Investigate Bile Acid Synthesis -- Use of Human Hepatocytes to Investigate Blood Coagulation Factor -- Use of Human Hepatocytes to Investigate HCV Infection -- The Use of Hepatocytes to Investigate HDV Infection: The HDV/HepaRG Model -- Rodent Models of Liver Repopulation -- Chimeric Mice with Humanized Liver: Tools for the Study of Drug Metabolism, Excretion, and Toxicity -- Bioartificial Liver Support Systems -- Human Hepatocyte Transplantation
Dimensions
unknown
Edition
1st ed. 2010.
Extent
1 online resource (XX, 554 p.)
File format
multiple file formats
Form of item
online
Isbn
9781607616887
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-1-60761-688-7
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)2670000000065673
  • (SSID)ssj0000449606
  • (PQKBManifestationID)11318239
  • (PQKBTitleCode)TC0000449606
  • (PQKBWorkID)10429284
  • (PQKB)10273572
  • (DE-He213)978-1-60761-688-7
  • (EXLCZ)992670000000065673

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