The Resource Mass spectrometry in drug metabolism and disposition : basic principles and applications, edited by Mike S. Lee, Mingshe Zhu

Mass spectrometry in drug metabolism and disposition : basic principles and applications, edited by Mike S. Lee, Mingshe Zhu

Label
Mass spectrometry in drug metabolism and disposition : basic principles and applications
Title
Mass spectrometry in drug metabolism and disposition
Title remainder
basic principles and applications
Statement of responsibility
edited by Mike S. Lee, Mingshe Zhu
Contributor
Subject
Language
eng
Summary
"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text"--Provided by publisher
Member of
Cataloging source
DNLM/DLC
Dewey number
615/.7
Illustrations
illustrations
Index
index present
LC call number
RM301.55
LC item number
.M367 2011
Literary form
non fiction
Nature of contents
bibliography
NLM call number
QV 38
NLM item number
.M37 2011
http://library.link/vocab/relatedWorkOrContributorDate
1960-
http://library.link/vocab/relatedWorkOrContributorName
  • Lee, Mike S.
  • Zhu, Mingshe
Series statement
Wiley series on pharmaceutical science and biotechnology: practices, applications, and methods
http://library.link/vocab/subjectName
  • Drugs
  • Metabolites
  • Mass spectrometry
  • Pharmaceutical Preparations
  • Biopharmaceutics
  • Drug Design
  • Mass Spectrometry
  • Pharmacokinetics
Label
Mass spectrometry in drug metabolism and disposition : basic principles and applications, edited by Mike S. Lee, Mingshe Zhu
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Contents
(Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice -- Theory and Instrumentation of Mass Spectrometry -- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification -- Mass Spectral Interpretation -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection -- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition -- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening -- High Resolution Mass Spectrometry and Drug Metabolite Identification -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging -- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions -- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS -- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress -- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery
Dimensions
25 cm.
Extent
xxi, 776 p.
Isbn
9780470401965
Lccn
2010028341
Other physical details
ill.
System control number
  • (CaMWU)u2216914-01umb_inst
  • 2388483
  • (Sirsi) i9780470401965
  • (OCoLC)648080364
Label
Mass spectrometry in drug metabolism and disposition : basic principles and applications, edited by Mike S. Lee, Mingshe Zhu
Publication
Bibliography note
Includes bibliographical references and index
Contents
(Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice -- Theory and Instrumentation of Mass Spectrometry -- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification -- Mass Spectral Interpretation -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection -- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition -- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening -- High Resolution Mass Spectrometry and Drug Metabolite Identification -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging -- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions -- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS -- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress -- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery
Dimensions
25 cm.
Extent
xxi, 776 p.
Isbn
9780470401965
Lccn
2010028341
Other physical details
ill.
System control number
  • (CaMWU)u2216914-01umb_inst
  • 2388483
  • (Sirsi) i9780470401965
  • (OCoLC)648080364

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