The Resource Mathematical Modelling of Chromosome Replication and Replicative Stress, by Jens Karschau, (electronic resource)

Mathematical Modelling of Chromosome Replication and Replicative Stress, by Jens Karschau, (electronic resource)

Label
Mathematical Modelling of Chromosome Replication and Replicative Stress
Title
Mathematical Modelling of Chromosome Replication and Replicative Stress
Statement of responsibility
by Jens Karschau
Creator
Author
Author
Subject
Language
  • eng
  • eng
Summary
DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next, and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive. This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome; and how is the spatial organization of replication factories achieved inside the nucleus of a cell? A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer
Member of
http://library.link/vocab/creatorName
Karschau, Jens
Dewey number
530.1
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsaut
EcevtiN5LJM
Language note
English
LC call number
QH505
Literary form
non fiction
Nature of contents
dictionaries
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
http://library.link/vocab/subjectName
  • Nucleic acids
  • Genetic engineering
  • Statistical physics
  • Biological and Medical Physics, Biophysics
  • Complex Systems
  • Nucleic Acid Chemistry
  • Genetic Engineering
  • Numerical and Computational Physics, Simulation
  • Statistical Physics and Dynamical Systems
Label
Mathematical Modelling of Chromosome Replication and Replicative Stress, by Jens Karschau, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references at the end of each chapters
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Introduction -- Optimal Origin Placement for Minimal Replication Time -- Actively Replicating Domains Randomly Associate into Replication Factories -- Summary and Conclusions
Dimensions
unknown
Edition
1st ed. 2015.
Extent
1 online resource (89 p.)
Form of item
online
Isbn
9783319088617
Media category
computer
Media type code
  • c
Other control number
10.1007/978-3-319-08861-7
Specific material designation
remote
System control number
  • (CKB)3710000000187227
  • (EBL)1783139
  • (OCoLC)894170156
  • (SSID)ssj0001297542
  • (PQKBManifestationID)11843391
  • (PQKBTitleCode)TC0001297542
  • (PQKBWorkID)11228686
  • (PQKB)11751014
  • (DE-He213)978-3-319-08861-7
  • (MiAaPQ)EBC1783139
  • (EXLCZ)993710000000187227
Label
Mathematical Modelling of Chromosome Replication and Replicative Stress, by Jens Karschau, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references at the end of each chapters
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Introduction -- Optimal Origin Placement for Minimal Replication Time -- Actively Replicating Domains Randomly Associate into Replication Factories -- Summary and Conclusions
Dimensions
unknown
Edition
1st ed. 2015.
Extent
1 online resource (89 p.)
Form of item
online
Isbn
9783319088617
Media category
computer
Media type code
  • c
Other control number
10.1007/978-3-319-08861-7
Specific material designation
remote
System control number
  • (CKB)3710000000187227
  • (EBL)1783139
  • (OCoLC)894170156
  • (SSID)ssj0001297542
  • (PQKBManifestationID)11843391
  • (PQKBTitleCode)TC0001297542
  • (PQKBWorkID)11228686
  • (PQKB)11751014
  • (DE-He213)978-3-319-08861-7
  • (MiAaPQ)EBC1783139
  • (EXLCZ)993710000000187227

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