The Resource Mouse Models for Drug Discovery : Methods and Protocols, edited by Gabriele Proetzel, Michael V. Wiles, (electronic resource)

Mouse Models for Drug Discovery : Methods and Protocols, edited by Gabriele Proetzel, Michael V. Wiles, (electronic resource)

Label
Mouse Models for Drug Discovery : Methods and Protocols
Title
Mouse Models for Drug Discovery
Title remainder
Methods and Protocols
Statement of responsibility
edited by Gabriele Proetzel, Michael V. Wiles
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field
Member of
Dewey number
615.580724
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
  • vihIrSW338U
  • F9nub0z-rVU
Image bit depth
0
Language note
English
LC call number
RM1-950
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
  • Proetzel, Gabriele.
  • Wiles, Michael V.
Series statement
Methods in Molecular Biology,
Series volume
602
http://library.link/vocab/subjectName
  • Toxicology
  • Medical laboratories
  • Zoology
  • Laboratory animals
  • Pharmacology/Toxicology
  • Laboratory Medicine
  • Zoology
  • Animal Models
Label
Mouse Models for Drug Discovery : Methods and Protocols, edited by Gabriele Proetzel, Michael V. Wiles, (electronic resource)
Instantiates
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains -- The Sophisticated Mouse: Protecting a Precious Reagent -- Genetically Engineered Mouse Models in Drug Discovery Research -- Engineering the Mouse Genome to Model Human Disease for Drug Discovery -- Profiling of Drug Action Using Reporter Mice and Molecular Imaging -- Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies -- Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease -- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans -- Mouse Models of Type II Diabetes Mellitus in Drug Discovery -- Cholesterol Absorption and Metabolism -- Collagen-Induced Arthritis in Mice -- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening -- Models of Metastasis in Drug Discovery -- Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging -- CML Mouse Model in Translational Research -- Mouse Models for Studying Depression-Like States and Antidepressant Drugs -- Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors -- Experimental Models of Anxiety for Drug Discovery and Brain Research -- Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology -- Neuromuscular Disease Models and Analysis -- Murine Model of Cutaneous Infection with Streptococcus pyogenes -- Murine Model of Pneumococcal Pneumonia -- Murine Model of Polymicrobial Septic Peritonitis Using Cecal Ligation and Puncture (CLP) -- Erratum to: Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies
Dimensions
unknown
Edition
1st ed. 2010.
Extent
1 online resource (XII, 421 p.)
File format
multiple file formats
Form of item
online
Isbn
9781607610588
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-1-60761-058-8
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)2670000000003412
  • (SSID)ssj0000327920
  • (PQKBManifestationID)11247139
  • (PQKBTitleCode)TC0000327920
  • (PQKBWorkID)10301649
  • (PQKB)10727966
  • (DE-He213)978-1-60761-058-8
  • (EXLCZ)992670000000003412
Label
Mouse Models for Drug Discovery : Methods and Protocols, edited by Gabriele Proetzel, Michael V. Wiles, (electronic resource)
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains -- The Sophisticated Mouse: Protecting a Precious Reagent -- Genetically Engineered Mouse Models in Drug Discovery Research -- Engineering the Mouse Genome to Model Human Disease for Drug Discovery -- Profiling of Drug Action Using Reporter Mice and Molecular Imaging -- Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies -- Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease -- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans -- Mouse Models of Type II Diabetes Mellitus in Drug Discovery -- Cholesterol Absorption and Metabolism -- Collagen-Induced Arthritis in Mice -- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening -- Models of Metastasis in Drug Discovery -- Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging -- CML Mouse Model in Translational Research -- Mouse Models for Studying Depression-Like States and Antidepressant Drugs -- Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors -- Experimental Models of Anxiety for Drug Discovery and Brain Research -- Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology -- Neuromuscular Disease Models and Analysis -- Murine Model of Cutaneous Infection with Streptococcus pyogenes -- Murine Model of Pneumococcal Pneumonia -- Murine Model of Polymicrobial Septic Peritonitis Using Cecal Ligation and Puncture (CLP) -- Erratum to: Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies
Dimensions
unknown
Edition
1st ed. 2010.
Extent
1 online resource (XII, 421 p.)
File format
multiple file formats
Form of item
online
Isbn
9781607610588
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-1-60761-058-8
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)2670000000003412
  • (SSID)ssj0000327920
  • (PQKBManifestationID)11247139
  • (PQKBTitleCode)TC0000327920
  • (PQKBWorkID)10301649
  • (PQKB)10727966
  • (DE-He213)978-1-60761-058-8
  • (EXLCZ)992670000000003412

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