The Resource Naloxone for respiratory depression in patients with drug or addiction issues : a review of the evidence on safety and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Naloxone for respiratory depression in patients with drug or addiction issues : a review of the evidence on safety and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Label
Naloxone for respiratory depression in patients with drug or addiction issues : a review of the evidence on safety and guidelines
Title
Naloxone for respiratory depression in patients with drug or addiction issues
Title remainder
a review of the evidence on safety and guidelines
Statement of responsibility
[prepared by Canadian Agency for Drugs and Technologies in Health]
Contributor
Subject
Genre
Language
eng
Summary
Natural or synthetic opioids can be used therapeutically, recreationally, and children may be unintentionally exposed to them. Opioid addiction and abuse is a major medical and social problem all around the world. Opioid antagonists are commonly used as rescue medications to reverse severe opioid-induced respiratory depression. Naloxone is a non-selective, short-acting opioid receptor antagonist which acts on the mu-, delta- and kappa-opioid receptors. It has been approved by Health Canada as an opioid antagonist since 1994.7 The most common use of naloxone is for the treatment of opioid overdose in both hospital and out-patient settings, and in rapid detoxification (being given intravenously [i.v.] when combined with other medications). The safety of naloxone is well established in patients and healthy volunteers over a wide dose range (0.4 to 10 mg). However, clinical studies have indicated that naloxone may be associated with serious adverse effects, such as pulmonary edema, cardiac arrhythmias, hypertension / hypotension, seizures, and violent behavior. In addition, continuous monitoring of naloxone is recommended due to its shorter duration of action. The purpose of this review is to assess the evidence of harms related to the use of naloxone in management of respiratory depression in patients with polypharmacy intoxication or opioid dependence. Evidence-based guidelines and recommendation for the dosing of naloxone in this population will also be discussed
Member of
Cataloging source
CaBNVSL
Dewey number
615.9/08
Illustrations
illustrations
Index
no index present
LC call number
RM302.2
LC item number
.N247 2012eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 601
NLM item number
N247 2012eb
http://library.link/vocab/relatedWorkOrContributorName
  • Canadian Agency for Drugs and Technologies in Health
  • Canadian Electronic Library (Firm)
Series statement
Rapid response report, summary with critical appraisal
http://library.link/vocab/subjectName
  • Naloxone
  • Naloxone
  • Naloxone
  • Naloxone
  • Opioid-Related Disorders
Label
Naloxone for respiratory depression in patients with drug or addiction issues : a review of the evidence on safety and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/234403
Instantiates
Publication
Note
  • "05 September 2012"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 6)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (8 p.)
Form of item
online
Other physical details
table, digital file.
Publisher number
234403
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00553551
  • (OCoLC)818083743
  • (CaOOCEL)234403
System details
Mode of access: World Wide Web
Label
Naloxone for respiratory depression in patients with drug or addiction issues : a review of the evidence on safety and guidelines, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/234403
Publication
Note
  • "05 September 2012"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 6)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (8 p.)
Form of item
online
Other physical details
table, digital file.
Publisher number
234403
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00553551
  • (OCoLC)818083743
  • (CaOOCEL)234403
System details
Mode of access: World Wide Web

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