The Resource Progress in molecular biology and translational science, Volume one hundred and thirty two, Trafficking of GPCRs, edited by Guangyu Wu, Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA

Progress in molecular biology and translational science, Volume one hundred and thirty two, Trafficking of GPCRs, edited by Guangyu Wu, Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA

Label
Progress in molecular biology and translational science, Volume one hundred and thirty two, Trafficking of GPCRs
Title
Progress in molecular biology and translational science
Title number
Volume one hundred and thirty two
Title part
Trafficking of GPCRs
Statement of responsibility
edited by Guangyu Wu, Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA
Contributor
Editor
Subject
Genre
Language
  • eng
  • eng
Member of
Cataloging source
MiAaPQ
Dewey number
570.285
Illustrations
  • illustrations
  • plates
Index
index present
Language note
English
LC call number
QP552.G16
LC item number
.P764 2015
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Wu, Guangyu
Series statement
Progress in Molecular Biology and Translational Science,
Series volume
Volume 132
http://library.link/vocab/subjectName
G proteins
Label
Progress in molecular biology and translational science, Volume one hundred and thirty two, Trafficking of GPCRs, edited by Guangyu Wu, Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA
Instantiates
Publication
Copyright
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Front Cover; Trafficking of GPCRs; Copyright; Contents; Contributors; Preface; Chapter 1: Arrestins: Critical Players in Trafficking of Many GPCRs*; 1. Arrestins and GPCR Trafficking; 2. Non-visual Arrestins Mediate GPCR Internalization via Coated Pits; 3. Visual Arrestins and Trafficking Proteins; 4. Ubiquitination and Deubiquitination in GPCR Cycling and Signaling; 5. Faster Cycling Prevents Receptor Downregulation; 6. Arrestins in Receptor Recycling and Vesicle Trafficking: Questions Without Answers; 7. Conclusions and Future Directions; References
  • Chapter 2: Regulation of GPCR Trafficking by Ubiquitin1. Introduction; 2. Ubiquitination Machinery; 3. Mechanisms of GPCR Ubiquitination; 4. GPCR Regulation by E3 Ubiquitin Ligases; 5. Role of Ubiquitin in GPCR Internalization; 6. Role of Ubiquitin in GPCR Endosome to Lysosome Sorting; 7. Role of Deubiquitination in GPCR Lysosomal Sorting; 8. Effect of Biased Agonism on GPCR Trafficking: Role of Ubiquitin; 9. Conclusion; Acknowledgments; References; Chapter 3: Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components, and Mechanisms; 1. Introduction
  • 2. Trafficking Signals of Rhodopsin3. Molecular Components and Mechanisms for Specific OS Targeting of Rhodopsin; 3.1. Biogenesis of Rhodopsin in Endoplasmic Reticulum and Subsequent Maturation in Golgi Apparatus; 3.2. Sorting of Rhodopsin at the Golgi Apparatus and Post-Golgi Trafficking; 3.3. Vectorial Targeting of Rhodopsin from Golgi to the Connecting Cilium: Possible Involvement of Microtubules; 3.4. Trafficking of Rhodopsin Toward the Distal End of the Connecting Cilium; 3.5. Trafficking of Rhodopsin Within the OS; 4. Mislocalization of Rhodopsin Mutants
  • 4.1. Mislocalization Due to Defects of Trafficking Signals4.2. Mislocalization Due to Misfolding; 4.3. Mislocalization Due to Aberrant Arrestin Binding; 5. Future Perspectives; Acknowledgment; References; Chapter 4: Intracellular Trafficking of Neuropeptide Y Receptors; 1. Introduction: The Neuropeptide Y Receptor Family; 2. Evolution of the NPY Receptor Family; 3. Intracellular Trafficking of Y Receptors; 3.1. Anterograde Transport of Y Receptors; 3.2. Internalization of Y Receptors; 3.2.1. Chimeric Receptors; 3.2.2. N-Terminal Sequences; 3.2.3. C-Terminal Sequences; 3.2.4. Sequences in ICLs
  • 3.2.5. Arrestin Binding3.3. Recycling of Y Receptors; 4. Modulation of Internalization by Ligand Modification; 5. Conclusions; References; Chapter 5: Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and Internalization; 1. Introduction; 2. Trafficking of the 5-HT1R; 2.1. The 5-HT1A Receptor; 2.1.1. 5-HT1AR Desensitization upon SSRI Treatment In Vivo; 2.1.2. 5-HT1AR Internalization in Cell Lines; 2.1.3. 5-HT1AR Internalization in Neuronal Cultures; 2.2. 5-HT1AR Addressing; 2.2.1. 5-HT1AR and 5-HT1BR Addressing in Polarized Cell Lines
  • 2.2.2. 5-HT1AR and 5-HT1BR Addressing in Neuronal Cultures
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (351 p.)
Form of item
online
Isbn
9780128029398
Media category
computer
Media type code
c
Specific material designation
remote
System control number
  • (CKB)2670000000619972
  • (EBL)2065194
  • (SSID)ssj0001549947
  • (PQKBManifestationID)16159347
  • (PQKBTitleCode)TC0001549947
  • (PQKBWorkID)14806740
  • (PQKB)10333575
  • (MiAaPQ)EBC2065194
  • (EXLCZ)992670000000619972
Label
Progress in molecular biology and translational science, Volume one hundred and thirty two, Trafficking of GPCRs, edited by Guangyu Wu, Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA
Publication
Copyright
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Front Cover; Trafficking of GPCRs; Copyright; Contents; Contributors; Preface; Chapter 1: Arrestins: Critical Players in Trafficking of Many GPCRs*; 1. Arrestins and GPCR Trafficking; 2. Non-visual Arrestins Mediate GPCR Internalization via Coated Pits; 3. Visual Arrestins and Trafficking Proteins; 4. Ubiquitination and Deubiquitination in GPCR Cycling and Signaling; 5. Faster Cycling Prevents Receptor Downregulation; 6. Arrestins in Receptor Recycling and Vesicle Trafficking: Questions Without Answers; 7. Conclusions and Future Directions; References
  • Chapter 2: Regulation of GPCR Trafficking by Ubiquitin1. Introduction; 2. Ubiquitination Machinery; 3. Mechanisms of GPCR Ubiquitination; 4. GPCR Regulation by E3 Ubiquitin Ligases; 5. Role of Ubiquitin in GPCR Internalization; 6. Role of Ubiquitin in GPCR Endosome to Lysosome Sorting; 7. Role of Deubiquitination in GPCR Lysosomal Sorting; 8. Effect of Biased Agonism on GPCR Trafficking: Role of Ubiquitin; 9. Conclusion; Acknowledgments; References; Chapter 3: Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components, and Mechanisms; 1. Introduction
  • 2. Trafficking Signals of Rhodopsin3. Molecular Components and Mechanisms for Specific OS Targeting of Rhodopsin; 3.1. Biogenesis of Rhodopsin in Endoplasmic Reticulum and Subsequent Maturation in Golgi Apparatus; 3.2. Sorting of Rhodopsin at the Golgi Apparatus and Post-Golgi Trafficking; 3.3. Vectorial Targeting of Rhodopsin from Golgi to the Connecting Cilium: Possible Involvement of Microtubules; 3.4. Trafficking of Rhodopsin Toward the Distal End of the Connecting Cilium; 3.5. Trafficking of Rhodopsin Within the OS; 4. Mislocalization of Rhodopsin Mutants
  • 4.1. Mislocalization Due to Defects of Trafficking Signals4.2. Mislocalization Due to Misfolding; 4.3. Mislocalization Due to Aberrant Arrestin Binding; 5. Future Perspectives; Acknowledgment; References; Chapter 4: Intracellular Trafficking of Neuropeptide Y Receptors; 1. Introduction: The Neuropeptide Y Receptor Family; 2. Evolution of the NPY Receptor Family; 3. Intracellular Trafficking of Y Receptors; 3.1. Anterograde Transport of Y Receptors; 3.2. Internalization of Y Receptors; 3.2.1. Chimeric Receptors; 3.2.2. N-Terminal Sequences; 3.2.3. C-Terminal Sequences; 3.2.4. Sequences in ICLs
  • 3.2.5. Arrestin Binding3.3. Recycling of Y Receptors; 4. Modulation of Internalization by Ligand Modification; 5. Conclusions; References; Chapter 5: Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and Internalization; 1. Introduction; 2. Trafficking of the 5-HT1R; 2.1. The 5-HT1A Receptor; 2.1.1. 5-HT1AR Desensitization upon SSRI Treatment In Vivo; 2.1.2. 5-HT1AR Internalization in Cell Lines; 2.1.3. 5-HT1AR Internalization in Neuronal Cultures; 2.2. 5-HT1AR Addressing; 2.2.1. 5-HT1AR and 5-HT1BR Addressing in Polarized Cell Lines
  • 2.2.2. 5-HT1AR and 5-HT1BR Addressing in Neuronal Cultures
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (351 p.)
Form of item
online
Isbn
9780128029398
Media category
computer
Media type code
c
Specific material designation
remote
System control number
  • (CKB)2670000000619972
  • (EBL)2065194
  • (SSID)ssj0001549947
  • (PQKBManifestationID)16159347
  • (PQKBTitleCode)TC0001549947
  • (PQKBWorkID)14806740
  • (PQKB)10333575
  • (MiAaPQ)EBC2065194
  • (EXLCZ)992670000000619972

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