The Resource Protease inhibitor use for chronic hepatitis C infection in prior null responders and recurrent hepatitis C infection post liver transplant : a review of the clinical evidence, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Protease inhibitor use for chronic hepatitis C infection in prior null responders and recurrent hepatitis C infection post liver transplant : a review of the clinical evidence, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)

Label
Protease inhibitor use for chronic hepatitis C infection in prior null responders and recurrent hepatitis C infection post liver transplant : a review of the clinical evidence
Title
Protease inhibitor use for chronic hepatitis C infection in prior null responders and recurrent hepatitis C infection post liver transplant
Title remainder
a review of the clinical evidence
Statement of responsibility
[prepared by Canadian Agency for Drugs and Technologies in Health]
Contributor
Subject
Genre
Language
eng
Summary
Chronic hepatitis C (CHC) remains a significant medical and economic burden in Canada, affecting nearly 1% of the population. In 2007, it was estimated that 242,000 Canadians had chronic HCV infection and about 7,000 new infections occurred. Of those with chronic infection,15% to 25% will develop progressive liver disease, end stage liver disease, hepatocellular carcinoma or will require liver transplant. Hepatitis C is the principal cause of death from liver disease and the leading indication for liver transplantation. Recurrence of HCV occurs in more than 95% of patients after liver transplantation. Boceprevir (BOC) and telaprevir (TP) are two NS3 protease inhibitors (PI) indicated for the treatment of CHC genotype 1 infection. They have shown statistically significant improvement of the SVR rate in patients with CHC who are treatment nav̐e or failed to respond to prior standard PR therapy. However, the comparative effectiveness and safety of triple therapy of BOC or TP plus PR compared with standard PR therapy alone in patients who are prior null responder (defined as less than 2 log10 HCV RNA reduction after 12 weeks of PR therapy) or patients who have recurrent HCV after liver transplantation were not well established. The addition of PI to the established PR regimen may provide another opportunity for patients who have had a null response to prior PR therapy. It is therefore important to ascertain the efficacy of PI-PR triple therapy in this population. The use of BOC or TP in the post-transplant setting in patients with genotype 1 HCV disease has been limited. It has been indicated that drug-drug (PI and immunosuppressive agents) interactions remain a significant clinical issue. The aim of this review is to evaluate the effective and safety evidence of BOC or TP-containing triple therapy regimens in the treatment of the above special populations
Member of
Cataloging source
CaBNVSL
Dewey number
572/.76
Illustrations
illustrations
Index
no index present
LC call number
QP609.P78
LC item number
P766 2013eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QU 136
NLM item number
P766 2013eb
http://library.link/vocab/relatedWorkOrContributorName
  • Canadian Agency for Drugs and Technologies in Health
  • Canadian Electronic Library (Firm)
Series statement
Rapid response report, summary with critical appraisal
http://library.link/vocab/subjectName
  • Protease inhibitors
  • Hepatitis C
  • Protease Inhibitors
  • Hepatitis C
Label
Protease inhibitor use for chronic hepatitis C infection in prior null responders and recurrent hepatitis C infection post liver transplant : a review of the clinical evidence, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/238338
Instantiates
Publication
Note
  • "29 May 2013"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 7-10)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (18 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
238338
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00556513
  • (OCoLC)855800463
  • (CaOOCEL)238338
System details
Mode of access: World Wide Web
Label
Protease inhibitor use for chronic hepatitis C infection in prior null responders and recurrent hepatitis C infection post liver transplant : a review of the clinical evidence, [prepared by Canadian Agency for Drugs and Technologies in Health], (electronic resource)
Link
http://www.deslibris.ca/ID/238338
Publication
Note
  • "29 May 2013"
  • Issued as part of the desLibris documents collection
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (p. 7-10)
Color
multicolored
Dimensions
unknown
Extent
1 electronic text (18 p.)
Form of item
online
Other physical details
tables, digital file.
Publisher number
238338
Specific material designation
remote
System control number
  • (CaBNVSL)gtp00556513
  • (OCoLC)855800463
  • (CaOOCEL)238338
System details
Mode of access: World Wide Web

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