The Resource Protein-Protein Interactions as New Drug Targets, edited by Enno Klussmann, John Scott, (electronic resource)

Protein-Protein Interactions as New Drug Targets, edited by Enno Klussmann, John Scott, (electronic resource)

Label
Protein-Protein Interactions as New Drug Targets
Title
Protein-Protein Interactions as New Drug Targets
Statement of responsibility
edited by Enno Klussmann, John Scott
Title variation
With contributions by numerous experts
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted
Member of
Is Subseries of
Dewey number
615.7
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
  • 8zyDPS-f2mg
  • xd6mgBPt9gs
Language note
English
LC call number
RM1-950
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Klussmann, Enno.
  • Scott, John.
Series statement
Handbook of Experimental Pharmacology,
Series volume
186
http://library.link/vocab/subjectName
  • Toxicology
  • Cytology
  • Biochemistry
  • Medicine
  • Pharmacology/Toxicology
  • Cell Biology
  • Medical Biochemistry
  • Molecular Medicine
Label
Protein-Protein Interactions as New Drug Targets, edited by Enno Klussmann, John Scott, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Organization of Scaffolds -- A-Kinase Anchoring Proteins as the Basis for cAMP Signaling -- Arrestins as Multi-Functional Signaling Adaptors -- Role of Ena/VASP Proteins in Homeostasis and Disease -- Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy -- Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox? -- Scaffolding Proteins and Cellular Signalling -- PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases -- G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains -- Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design -- Compartmentalised MAPK Pathways -- Dynamic Protein Complexes Regulate NF-?B Signaling -- An Oncogenic Hub: ?-Catenin as a Molecular Target for Cancer Therapeutics -- A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling -- Cell Type-Specific Anchoring -- Scaffolding Proteins in Cardiac Myocytes -- Molecular Architecture of Signal Complexes Regulating Immune Cell Function -- Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework -- Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept -- Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies -- Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition -- Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors -- Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs -- Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets
Dimensions
unknown
Edition
1st ed. 2008.
Extent
1 online resource (523 p.)
Form of item
online
Isbn
9786611493721
Media category
computer
Media type code
  • c
Other control number
10.1007/978-3-540-72843-6
Specific material designation
remote
System control number
  • (CKB)1000000000401121
  • (EBL)372597
  • (OCoLC)272310007
  • (SSID)ssj0000229651
  • (PQKBManifestationID)11206201
  • (PQKBTitleCode)TC0000229651
  • (PQKBWorkID)10172358
  • (PQKB)10645858
  • (DE-He213)978-3-540-72843-6
  • (MiAaPQ)EBC372597
  • (EXLCZ)991000000000401121
Label
Protein-Protein Interactions as New Drug Targets, edited by Enno Klussmann, John Scott, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Organization of Scaffolds -- A-Kinase Anchoring Proteins as the Basis for cAMP Signaling -- Arrestins as Multi-Functional Signaling Adaptors -- Role of Ena/VASP Proteins in Homeostasis and Disease -- Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy -- Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox? -- Scaffolding Proteins and Cellular Signalling -- PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases -- G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains -- Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design -- Compartmentalised MAPK Pathways -- Dynamic Protein Complexes Regulate NF-?B Signaling -- An Oncogenic Hub: ?-Catenin as a Molecular Target for Cancer Therapeutics -- A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling -- Cell Type-Specific Anchoring -- Scaffolding Proteins in Cardiac Myocytes -- Molecular Architecture of Signal Complexes Regulating Immune Cell Function -- Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework -- Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept -- Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies -- Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition -- Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors -- Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs -- Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets
Dimensions
unknown
Edition
1st ed. 2008.
Extent
1 online resource (523 p.)
Form of item
online
Isbn
9786611493721
Media category
computer
Media type code
  • c
Other control number
10.1007/978-3-540-72843-6
Specific material designation
remote
System control number
  • (CKB)1000000000401121
  • (EBL)372597
  • (OCoLC)272310007
  • (SSID)ssj0000229651
  • (PQKBManifestationID)11206201
  • (PQKBTitleCode)TC0000229651
  • (PQKBWorkID)10172358
  • (PQKB)10645858
  • (DE-He213)978-3-540-72843-6
  • (MiAaPQ)EBC372597
  • (EXLCZ)991000000000401121

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