The Resource The structure of biological membranes, edited by Philip L. Yeagle

The structure of biological membranes, edited by Philip L. Yeagle

Label
The structure of biological membranes
Title
The structure of biological membranes
Statement of responsibility
edited by Philip L. Yeagle
Contributor
Subject
Language
eng
Summary
"Biological membranes provide the fundamental structure of cells and viruses. Because much of what happens in a cell or in a virus occurs on, in, or across biological membranes, the study of membranes has rapidly permeated the fields of biology, pharmaceutical chemistry, and materials science. The Structure of Biological Membranes, Third Edition provides readers with an understanding of membrane structure and function that is rooted in the history of the field and brought to the forefront of current knowledge.The first part of the book focuses on the fundamentals of lipid bilayers and membrane proteins. Three introductory chapters supply those new to the field with the tools and conceptual framework with which to approach the state-of-the-art chapters that follow. The second part of the book presents in-depth analyses of focused subjects within the study of membranes, covering topics that include: Phase behavior of lipid bilayers as an isolated structure, Cholesterol's role in cell biology, Lateral organization of membranes, The role of membrane lipids in initial membrane protein folding, Membrane protein synthesis and assembly of oligomeric membrane proteins, Membrane protein stability with relationships to function and protein turnover, Membrane protein function using a transport protein, Interactions between membrane proteins and membrane lipids. A final chapter pulls together many of the topics, examining in detail the complexity inherent in the synthesis and assembly of lipids and proteins in mitochondrial membranes. With contributions from leading researchers, this completely revised and updated third edition reflects recent advances in the field of biological membranes."--Provided by publisher
Cataloging source
DNLM/DLC
Dewey number
571.6/4
Illustrations
illustrations
Index
index present
LC call number
QH601
LC item number
.S777 2012
Literary form
non fiction
Nature of contents
bibliography
NLM call number
QU 350
http://library.link/vocab/relatedWorkOrContributorName
Yeagle, Philip
http://library.link/vocab/subjectName
  • Membranes (Biology)
  • Membrane proteins
  • Membrane lipids
  • Cell Membrane
  • Membrane Lipids
  • Membrane Proteins
Label
The structure of biological membranes, edited by Philip L. Yeagle
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Contents
  • Membrane Proteins
  • Fundamental Properties of Cholesterol in Membrane Bilayers
  • Sterol Ordering of Membranes
  • Cholesterol Ordering of Membranes and Alteration of Membrane Function
  • Summary
  • References
  • ch. 7
  • Functional Consequences of the Lateral Organization of Biological Membranes
  • Raquel F. Epand
  • Key Concepts
  • Introduction
  • Philip L. Yeagle
  • Dimensions of Domains
  • Lifetime of Domains
  • Asymmetry of Domains
  • Cholesterol and Domains
  • Anionic Lipids and Domains
  • Bacterial Membrane Domains
  • Functional Consequences of the Existence of Domains
  • References
  • ch. 8
  • Mechanisms by Which Pathogens Hijack and Utilize Membrane Domains to Mediate Cytotoxicity
  • Fundamentals of Structure
  • Kathleen Boesze-Battaglia
  • Introduction
  • Membrane Fusion by Herpes Simplex Virus Type 1
  • Membrane Fusion during HSV-1 Entry
  • Fusion during Virus Nuclear Egress
  • Cytolethal Distending Toxin---Lipid-Mediated Mode of Entry and Mechanism of Action
  • Cholesterol-Dependent Cell Surface Binding
  • CdtB Phosphatase Activity May Determine Cell Sensitivity
  • Actinobacillus Actinomycetemcomitans Leukotoxin (LtxA) Induced Changes in Bilayer Structure
  • Membrane-Specific Changes or Hijack Mechanisms
  • References
  • Hijacking of Lipid Rafts
  • Induction of Hexagonal II (H II) Phase
  • Acknowledgments
  • References
  • ch. 9
  • Lipid-Assisted Membrane Protein Folding and Topogenesis
  • Mikhail Bogdanov
  • Introduction
  • Membrane Protein Synthesis, Assembly, and Structure
  • Development of Systems for Altering Membrane Lipid Composition
  • ch. 3
  • Lipids as Molecular Chaperones during Membrane Protein Assembly
  • Organization of LacY in the Absence of PE
  • Lipid-Protein Interactions as Topological Determinants
  • Properties of Lipids That Influence Structure and Function
  • Final Topology Dependent on Multiple Factors
  • Lipids and Protein Folding Disorders
  • Conclusions and Perspectives
  • Acknowledgments
  • References
  • ch. 10
  • Introduction to Lipid-Protein Interactions in Biological Membranes
  • Membrane Protein Biogenesis and Assembly at the Endoplasmic Reticulum Membrane
  • Debra A. Kendall
  • Introduction
  • Signal Peptides
  • Types of Signal Peptides
  • Membrane Protein Topology
  • Transport Components
  • Signal Peptide Recognition Particle
  • SRP Receptor
  • Sec Translocon
  • Philip L. Yeagle
  • Accessory Components
  • Translocation across the ER Membrane
  • Transmembrane Segment Considerations
  • TM Recognition
  • TM Release
  • TM Stability
  • Topological Orientation of Membrane Proteins
  • Lipid Bilayer Effects
  • Interhelix Interactions in Multimeric Proteins
  • Summary
  • General Considerations of the Lipid-Protein Interface
  • Acknowledgments
  • References
  • ch. 11
  • Thermal Denaturation of Membrane Proteins
  • Arlene D. Albert
  • Introduction
  • Detection of Membrane Protein Thermal Stability
  • Reversible and Irreversible Denaturation: Thermodynamic and Kinetic Thermal Stability
  • What Can Thermal Denaturation Indicate about Membrane Protein Structural Stability?
  • Protein Thermal Denaturation Events
  • Interactions between the Hydrophobic Lipid Hydrocarbon Chains and Membrane Proteins
  • Contribution of Loops and Helices
  • Thermodynamically Stabilized Secondary Structures Fold into a Kinetically Stabilized Protein
  • Role of the Bilayer in Membrane Protein Stability
  • Conclusion
  • References
  • ch. 12
  • Mass Action Kinetic Analysis of Multidrug Resistance Transporters Expressed in Confluent Cell Monolayers
  • Joe Bentz
  • History of Multidrug Resistance and the Role of P-Glycoprotein (MDRI)
  • Current Views of P-gp Structure
  • Interactions between the Hydrophilic Lipid Headgroups and Membrane Proteins
  • Experimental Systems Used to Study P-gp Function
  • Mass Action Kinetic Model
  • Mass Action Kinetic Reactions
  • Data Analysis for P-gp-Mediated Transport
  • Value of a More Rigorous Kinetic Analysis of P-gp Transport
  • With Confluent Cell Monolayers, Is the Michaelis-Menten Steady-State Analysis Accurate?
  • With Confluent Cell Monolayers the IC50/K1 Ratio for Inhibitors Depends Completely upon Probe-Substrate Kinetic Parameters
  • Kinetic Identification of Other Transporters
  • Problem with Uptake Studies
  • Is P-gp a Flippase or a Transporter?
  • Machine generated contents note:
  • Dynamics of Lipid-Protein Interactions
  • How Can We Know Whether There Are Two or Three Kinetic Barriers across the Confluent Cell Monolayer?
  • OATP Family of Transporters
  • Conclusions
  • References
  • ch. 13
  • How to Understand Lipid-Protein Interactions in Biological Membranes
  • Anthony G. Lee
  • Lipids in Biological Membranes
  • Lipid Bilayer Is Important for Function
  • Importance of Chemical Specificity in Lipid-Protein Interactions
  • References
  • Solvation by Lipids
  • Physical Properties of the Lipid Bilayer
  • Fluidity
  • Bilayer Thickness
  • Spontaneous Curvature
  • Elastic Properties of Lipid Bilayers
  • How the Elastic Properties of a Membrane Might Affect Membrane Protein Function
  • Membrane Protein Distortion
  • Helix Tilting
  • Change in Protein Volume
  • ch. 4
  • Protein Aggregation
  • Pressure Profiles and Spontaneous Curvature
  • Experimental Data
  • Experimental Studies of the Effects of Bilayer Thickness
  • Experimental Studies of the Effects of Spontaneous Curvature and Pressure Profile
  • Conclusions and Biological Relevance
  • References
  • ch. 14
  • Biogenesis of Lipids and Proteins within Mitochondrial Membranes
  • Nathan Alder
  • Mesomorphic Phase Behavior of Lipid Bilayers
  • Introduction
  • Mitochondrial Membrane Structure and Composition
  • Organization and Dynamics of Mitochondrial Membranes
  • Molecular Basis of IM Morphology
  • Interaction between Mitochondria and the ER Membrane
  • Functional Significance of the MAM-Mitochondria Interface
  • Role of the MAM in Ca2+ Signaling and Homeostasis
  • Role of the MAM in Lipid Synthesis and Trafficking
  • Mechanisms of Mitochondrial Lipid Biogenesis
  • Lipid Composition of Mitochondria
  • Ronald N. McElhaney
  • Mechanisms of Mitochondrial Lipid Transport
  • Aminoglycerophospholipid Synthesis and Trafficking
  • Phosphatidylserine
  • Phosphatidylethanolamine
  • Phosphatidylcholine
  • CL Biosynthesis
  • Sterol Transport --
  • Introduction
  • Differential Scanning Calorimetry
  • Studies of Model Membranes
  • Thermotropic Phase Behavior of Dipalmitoylphosphatidylcholine
  • Lyotropic Phase Behavior of DPPC
  • ch. 1
  • Barotropic Phase Behavior of DPPC
  • Effect of Vesicle Size on the Thermotropic Phase Behavior of DPPC
  • Effect of Variations in the Length and Structure of the Hydrocarbon Chains on Lipid Thermotropic Phase Behavior
  • Variations in Hydrocarbon Chain Length
  • Variations in Hydrocarbon Chain Structure
  • Mixed-Chain Diacyl Phosphatidylcholines
  • Effect of the Variations in the Chemical Structure of the Polar Headgroup Structure on Lipid Thermotropic Phase Behavior
  • Effect of Size
  • Effect of Charge
  • Effect of Hydrogen Bonding
  • Introduction to Lipid Bilayers
  • Miscellaneous Effects
  • Effect of Variations in the Chemical Structure of the Glycerol Backbone Region on Lipid Thermotropic Phase Behavior
  • Effect of Chirality
  • 1,3-Diacyl Glycerolipids
  • Glycerolipids with Ether-Linked Hydrocarbon Chains
  • Lipids with Interfacial Amide Groups
  • Lipids with "Conformationally Restricted Glycerol Backbones"
  • Thermotropic Phase Behavior of Lipid Mixtures
  • Effect of Sterols on the Thermotropic Phase Behavior of Phospholipids
  • Effects of Cholesterol
  • Philip L. Yeagle
  • Effects of Other Sterols
  • Effect of Small Molecules on the Thermotropic Phase Behavior of Phospholipids
  • Effect of Transmembrane Peptides on Lipid Thermotropic Phase Behavior
  • Effect of Proteins on the Thermotropic Phase Behavior of Phospholipids
  • Studies of Biological Membranes
  • Mycoplasma and Bacterial Membranes
  • Eukaryotic Cell Membranes
  • Concluding Remarks
  • Acknowledgments
  • References
  • Lipid Bilayer
  • ch. 5
  • IR Spectroscopy of Lipid Chains: Theoretical Background and Applications to Phase Transitions, Membranes, Cells, and Tissues
  • Richard Mendelsohn
  • Introduction
  • Background
  • Motions of an Isolated Methylene Group
  • Models for Coupled Oscillators
  • Dispersion Curves: Models and Polyethylene
  • Vibrations of n-Paraffins: The Coupled Oscillator Model
  • Lipid Dispersions: Experimental Observations
  • Lipid Bilayer Properties
  • Gel-Liquid Crystal Phase Transitions
  • CH2 Stretching Region
  • CH2 Wagging Mode Progressions
  • CH2 Rocking and Scissoring Mode Contours
  • Effects of Chain Unsaturation
  • Applications to Biological Systems
  • Phase Transitions in Phospholipid Suspensions
  • Chain Vibrations
  • Studies of the Interfacial Region
  • Pressure as an Experimental Variable
  • References
  • Seissoring Contour
  • Kinetics of Domain Formation
  • Domain Sizes in Disordered Lipid Phases
  • Wagging Modes in Disordered Phases: Quantitative Estimates of Chain Conformational Disorder
  • Extensions to Intact Membranes and Whole Cells
  • Lipid Asymmetry, Conformational Order, and Domain Formation in Intact Cell Membranes
  • Extension to Tissues
  • Permeability Barrier in Skin
  • Vibrational Imaging Applications
  • Applications to Disease States
  • ch. 2
  • Future Directions
  • Acknowledgments
  • References
  • ch. 6
  • Roles of Cholesterol in the Biology of Cells
  • Philip L. Yeagle
  • Introduction
  • Molecular Evolution of Cholesterol
  • Functional Evolution of Cholesterol
  • Molecular Basis for Specificity of Sterols in Support of Cell Growth
  • Mitochondrial Protein Translocases
  • Biogenesis of Mitochondrial OM Proteins
  • Integration of β-Barrel Proteins: An Evolutionarily Conserved Mechanism
  • Integration of α-Helical Proteins: Diverse Mechanisms
  • Biogenesis of Mitochondrial IM Proteins
  • Integration of Polytopic Membrane Proteins with Internal Signal Sequences
  • Integration of Presequence-Containing Membrane Proteins
  • Integration by the OXA Complex
  • Mitochondrial Membrane Protein Assembly
  • Choreography of TOM Complex Assembly
  • Contents note continued:
  • Assembly of Respiratory Complexes
  • Membrane Protein Supercomplexes
  • Perspectives
  • Acknowledgments
  • References
  • Mechanisms of Mitochondrial Membrane Protein Biogenesis
  • Physical Principles of Membrane Protein Integration
  • Prokaryotic Membrane Protein Integration Complexes
  • Protein Transport and Integration at the Bacterial IM
  • Biogenesis of Bacterial OM Proteins
  • Mitochondrial Protein Translocation Systems: Overview
  • Targeting Proteins to the Mitochondrion
Dimensions
27 cm.
Edition
3rd ed.
Extent
xii, 386 p.
Isbn
9781439809570
Isbn Type
(hardback : alk. paper)
Lccn
2011027921
Other physical details
ill.
System control number
  • (CaMWU)u2449054-01umb_inst
  • 2464040
  • (Sirsi) i9781439809570
  • (OCoLC)739835745
Label
The structure of biological membranes, edited by Philip L. Yeagle
Publication
Bibliography note
Includes bibliographical references and index
Contents
  • Membrane Proteins
  • Fundamental Properties of Cholesterol in Membrane Bilayers
  • Sterol Ordering of Membranes
  • Cholesterol Ordering of Membranes and Alteration of Membrane Function
  • Summary
  • References
  • ch. 7
  • Functional Consequences of the Lateral Organization of Biological Membranes
  • Raquel F. Epand
  • Key Concepts
  • Introduction
  • Philip L. Yeagle
  • Dimensions of Domains
  • Lifetime of Domains
  • Asymmetry of Domains
  • Cholesterol and Domains
  • Anionic Lipids and Domains
  • Bacterial Membrane Domains
  • Functional Consequences of the Existence of Domains
  • References
  • ch. 8
  • Mechanisms by Which Pathogens Hijack and Utilize Membrane Domains to Mediate Cytotoxicity
  • Fundamentals of Structure
  • Kathleen Boesze-Battaglia
  • Introduction
  • Membrane Fusion by Herpes Simplex Virus Type 1
  • Membrane Fusion during HSV-1 Entry
  • Fusion during Virus Nuclear Egress
  • Cytolethal Distending Toxin---Lipid-Mediated Mode of Entry and Mechanism of Action
  • Cholesterol-Dependent Cell Surface Binding
  • CdtB Phosphatase Activity May Determine Cell Sensitivity
  • Actinobacillus Actinomycetemcomitans Leukotoxin (LtxA) Induced Changes in Bilayer Structure
  • Membrane-Specific Changes or Hijack Mechanisms
  • References
  • Hijacking of Lipid Rafts
  • Induction of Hexagonal II (H II) Phase
  • Acknowledgments
  • References
  • ch. 9
  • Lipid-Assisted Membrane Protein Folding and Topogenesis
  • Mikhail Bogdanov
  • Introduction
  • Membrane Protein Synthesis, Assembly, and Structure
  • Development of Systems for Altering Membrane Lipid Composition
  • ch. 3
  • Lipids as Molecular Chaperones during Membrane Protein Assembly
  • Organization of LacY in the Absence of PE
  • Lipid-Protein Interactions as Topological Determinants
  • Properties of Lipids That Influence Structure and Function
  • Final Topology Dependent on Multiple Factors
  • Lipids and Protein Folding Disorders
  • Conclusions and Perspectives
  • Acknowledgments
  • References
  • ch. 10
  • Introduction to Lipid-Protein Interactions in Biological Membranes
  • Membrane Protein Biogenesis and Assembly at the Endoplasmic Reticulum Membrane
  • Debra A. Kendall
  • Introduction
  • Signal Peptides
  • Types of Signal Peptides
  • Membrane Protein Topology
  • Transport Components
  • Signal Peptide Recognition Particle
  • SRP Receptor
  • Sec Translocon
  • Philip L. Yeagle
  • Accessory Components
  • Translocation across the ER Membrane
  • Transmembrane Segment Considerations
  • TM Recognition
  • TM Release
  • TM Stability
  • Topological Orientation of Membrane Proteins
  • Lipid Bilayer Effects
  • Interhelix Interactions in Multimeric Proteins
  • Summary
  • General Considerations of the Lipid-Protein Interface
  • Acknowledgments
  • References
  • ch. 11
  • Thermal Denaturation of Membrane Proteins
  • Arlene D. Albert
  • Introduction
  • Detection of Membrane Protein Thermal Stability
  • Reversible and Irreversible Denaturation: Thermodynamic and Kinetic Thermal Stability
  • What Can Thermal Denaturation Indicate about Membrane Protein Structural Stability?
  • Protein Thermal Denaturation Events
  • Interactions between the Hydrophobic Lipid Hydrocarbon Chains and Membrane Proteins
  • Contribution of Loops and Helices
  • Thermodynamically Stabilized Secondary Structures Fold into a Kinetically Stabilized Protein
  • Role of the Bilayer in Membrane Protein Stability
  • Conclusion
  • References
  • ch. 12
  • Mass Action Kinetic Analysis of Multidrug Resistance Transporters Expressed in Confluent Cell Monolayers
  • Joe Bentz
  • History of Multidrug Resistance and the Role of P-Glycoprotein (MDRI)
  • Current Views of P-gp Structure
  • Interactions between the Hydrophilic Lipid Headgroups and Membrane Proteins
  • Experimental Systems Used to Study P-gp Function
  • Mass Action Kinetic Model
  • Mass Action Kinetic Reactions
  • Data Analysis for P-gp-Mediated Transport
  • Value of a More Rigorous Kinetic Analysis of P-gp Transport
  • With Confluent Cell Monolayers, Is the Michaelis-Menten Steady-State Analysis Accurate?
  • With Confluent Cell Monolayers the IC50/K1 Ratio for Inhibitors Depends Completely upon Probe-Substrate Kinetic Parameters
  • Kinetic Identification of Other Transporters
  • Problem with Uptake Studies
  • Is P-gp a Flippase or a Transporter?
  • Machine generated contents note:
  • Dynamics of Lipid-Protein Interactions
  • How Can We Know Whether There Are Two or Three Kinetic Barriers across the Confluent Cell Monolayer?
  • OATP Family of Transporters
  • Conclusions
  • References
  • ch. 13
  • How to Understand Lipid-Protein Interactions in Biological Membranes
  • Anthony G. Lee
  • Lipids in Biological Membranes
  • Lipid Bilayer Is Important for Function
  • Importance of Chemical Specificity in Lipid-Protein Interactions
  • References
  • Solvation by Lipids
  • Physical Properties of the Lipid Bilayer
  • Fluidity
  • Bilayer Thickness
  • Spontaneous Curvature
  • Elastic Properties of Lipid Bilayers
  • How the Elastic Properties of a Membrane Might Affect Membrane Protein Function
  • Membrane Protein Distortion
  • Helix Tilting
  • Change in Protein Volume
  • ch. 4
  • Protein Aggregation
  • Pressure Profiles and Spontaneous Curvature
  • Experimental Data
  • Experimental Studies of the Effects of Bilayer Thickness
  • Experimental Studies of the Effects of Spontaneous Curvature and Pressure Profile
  • Conclusions and Biological Relevance
  • References
  • ch. 14
  • Biogenesis of Lipids and Proteins within Mitochondrial Membranes
  • Nathan Alder
  • Mesomorphic Phase Behavior of Lipid Bilayers
  • Introduction
  • Mitochondrial Membrane Structure and Composition
  • Organization and Dynamics of Mitochondrial Membranes
  • Molecular Basis of IM Morphology
  • Interaction between Mitochondria and the ER Membrane
  • Functional Significance of the MAM-Mitochondria Interface
  • Role of the MAM in Ca2+ Signaling and Homeostasis
  • Role of the MAM in Lipid Synthesis and Trafficking
  • Mechanisms of Mitochondrial Lipid Biogenesis
  • Lipid Composition of Mitochondria
  • Ronald N. McElhaney
  • Mechanisms of Mitochondrial Lipid Transport
  • Aminoglycerophospholipid Synthesis and Trafficking
  • Phosphatidylserine
  • Phosphatidylethanolamine
  • Phosphatidylcholine
  • CL Biosynthesis
  • Sterol Transport --
  • Introduction
  • Differential Scanning Calorimetry
  • Studies of Model Membranes
  • Thermotropic Phase Behavior of Dipalmitoylphosphatidylcholine
  • Lyotropic Phase Behavior of DPPC
  • ch. 1
  • Barotropic Phase Behavior of DPPC
  • Effect of Vesicle Size on the Thermotropic Phase Behavior of DPPC
  • Effect of Variations in the Length and Structure of the Hydrocarbon Chains on Lipid Thermotropic Phase Behavior
  • Variations in Hydrocarbon Chain Length
  • Variations in Hydrocarbon Chain Structure
  • Mixed-Chain Diacyl Phosphatidylcholines
  • Effect of the Variations in the Chemical Structure of the Polar Headgroup Structure on Lipid Thermotropic Phase Behavior
  • Effect of Size
  • Effect of Charge
  • Effect of Hydrogen Bonding
  • Introduction to Lipid Bilayers
  • Miscellaneous Effects
  • Effect of Variations in the Chemical Structure of the Glycerol Backbone Region on Lipid Thermotropic Phase Behavior
  • Effect of Chirality
  • 1,3-Diacyl Glycerolipids
  • Glycerolipids with Ether-Linked Hydrocarbon Chains
  • Lipids with Interfacial Amide Groups
  • Lipids with "Conformationally Restricted Glycerol Backbones"
  • Thermotropic Phase Behavior of Lipid Mixtures
  • Effect of Sterols on the Thermotropic Phase Behavior of Phospholipids
  • Effects of Cholesterol
  • Philip L. Yeagle
  • Effects of Other Sterols
  • Effect of Small Molecules on the Thermotropic Phase Behavior of Phospholipids
  • Effect of Transmembrane Peptides on Lipid Thermotropic Phase Behavior
  • Effect of Proteins on the Thermotropic Phase Behavior of Phospholipids
  • Studies of Biological Membranes
  • Mycoplasma and Bacterial Membranes
  • Eukaryotic Cell Membranes
  • Concluding Remarks
  • Acknowledgments
  • References
  • Lipid Bilayer
  • ch. 5
  • IR Spectroscopy of Lipid Chains: Theoretical Background and Applications to Phase Transitions, Membranes, Cells, and Tissues
  • Richard Mendelsohn
  • Introduction
  • Background
  • Motions of an Isolated Methylene Group
  • Models for Coupled Oscillators
  • Dispersion Curves: Models and Polyethylene
  • Vibrations of n-Paraffins: The Coupled Oscillator Model
  • Lipid Dispersions: Experimental Observations
  • Lipid Bilayer Properties
  • Gel-Liquid Crystal Phase Transitions
  • CH2 Stretching Region
  • CH2 Wagging Mode Progressions
  • CH2 Rocking and Scissoring Mode Contours
  • Effects of Chain Unsaturation
  • Applications to Biological Systems
  • Phase Transitions in Phospholipid Suspensions
  • Chain Vibrations
  • Studies of the Interfacial Region
  • Pressure as an Experimental Variable
  • References
  • Seissoring Contour
  • Kinetics of Domain Formation
  • Domain Sizes in Disordered Lipid Phases
  • Wagging Modes in Disordered Phases: Quantitative Estimates of Chain Conformational Disorder
  • Extensions to Intact Membranes and Whole Cells
  • Lipid Asymmetry, Conformational Order, and Domain Formation in Intact Cell Membranes
  • Extension to Tissues
  • Permeability Barrier in Skin
  • Vibrational Imaging Applications
  • Applications to Disease States
  • ch. 2
  • Future Directions
  • Acknowledgments
  • References
  • ch. 6
  • Roles of Cholesterol in the Biology of Cells
  • Philip L. Yeagle
  • Introduction
  • Molecular Evolution of Cholesterol
  • Functional Evolution of Cholesterol
  • Molecular Basis for Specificity of Sterols in Support of Cell Growth
  • Mitochondrial Protein Translocases
  • Biogenesis of Mitochondrial OM Proteins
  • Integration of β-Barrel Proteins: An Evolutionarily Conserved Mechanism
  • Integration of α-Helical Proteins: Diverse Mechanisms
  • Biogenesis of Mitochondrial IM Proteins
  • Integration of Polytopic Membrane Proteins with Internal Signal Sequences
  • Integration of Presequence-Containing Membrane Proteins
  • Integration by the OXA Complex
  • Mitochondrial Membrane Protein Assembly
  • Choreography of TOM Complex Assembly
  • Contents note continued:
  • Assembly of Respiratory Complexes
  • Membrane Protein Supercomplexes
  • Perspectives
  • Acknowledgments
  • References
  • Mechanisms of Mitochondrial Membrane Protein Biogenesis
  • Physical Principles of Membrane Protein Integration
  • Prokaryotic Membrane Protein Integration Complexes
  • Protein Transport and Integration at the Bacterial IM
  • Biogenesis of Bacterial OM Proteins
  • Mitochondrial Protein Translocation Systems: Overview
  • Targeting Proteins to the Mitochondrion
Dimensions
27 cm.
Edition
3rd ed.
Extent
xii, 386 p.
Isbn
9781439809570
Isbn Type
(hardback : alk. paper)
Lccn
2011027921
Other physical details
ill.
System control number
  • (CaMWU)u2449054-01umb_inst
  • 2464040
  • (Sirsi) i9781439809570
  • (OCoLC)739835745

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    2340 Pembina Highway, Winnipeg, MB, R3T 2E8, CA
    49.806755 -97.152739
  • William R Newman Library (Agriculture)Borrow it
    66 Dafoe Road, Winnipeg, MB, R3T 2R3, CA
    49.806936 -97.135525
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