The Resource Ubiquitination and transmembrane signaling, edited by Sudha K. Shenoy

Ubiquitination and transmembrane signaling, edited by Sudha K. Shenoy

Label
Ubiquitination and transmembrane signaling
Title
Ubiquitination and transmembrane signaling
Statement of responsibility
edited by Sudha K. Shenoy
Contributor
Author
Subject
Genre
Language
eng
Member of
Cataloging source
MiAaPQ
Dewey number
572.696
Illustrations
  • illustrations
  • plates
Index
index present
LC call number
QP552.M44
LC item number
.U257 2016
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Shenoy, Sudha K.
Series statement
Progress in Molecular Biology and Translational Science,
Series volume
Volume 141
http://library.link/vocab/subjectName
  • Membrane proteins
  • Ubiquitin
Label
Ubiquitination and transmembrane signaling, edited by Sudha K. Shenoy
Instantiates
Publication
Copyright
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Contents
  • Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter One - Ubiquitination and Deubiquitination of G Protein-Coupled Receptors; Abstract; 1 Introduction; 1.1 G Protein-Coupled Receptors; 1.2 Ubiquitination and Deubiquitination; 2 Ubiquitination of GPCRs; 2.1 ß2 Adrenergic Receptor; 2.2 Chemokine Receptors; 2.2.1 CXCR2; 2.2.2 CXCR4; 2.2.3 CXCR7; 2.2.4 CCR7; 2.3 Proteinase Activated Receptors; 2.3.1 PAR1; 2.3.2 PAR2; 2.4 Opioid Receptors; 2.5 Noncanonical GPCRs and Ubiquitin Ligases; 2.5.1 Wnt/ß-Catenin Signaling; 2.5.2 Hedgehog Signaling; 2.6 Yeast GPCRs
  • 3 Deubiquitination of GPCRs3.1 Overview; 3.2 Recycling and Resensitization; 3.2.1 ß2AR; 3.2.2 PTH1R; 3.2.3 Frizzled and Smoothened; 3.3 Accelerated Degradation; 3.3.1 PAR2; 3.3.2 CXCR4; 3.4 Alternate Effects; 3.4.1 Metabotropic ?-Aminobutyric Acid Receptor (GABABR); 4 Concluding Remarks; Acknowledgments; References; Chapter Two - Heterotrimeric G Protein Ubiquitination as a Regulator of G Protein Signaling; Abstract; 1 Introduction; 2 Ubiquitination of Heterotrimeric G Proteins-Evidence From the Yeast Model System; 2.1 Yeast Ga/Gpa1 as a Model for G Protein Ubiquitination Studies
  • 2.2 Initiating Signals for G Protein Ubiquitination in Yeast2.3 Yeast G Protein Ubiquitin Ligases; 2.4 Trafficking Pathways of Monoubiquitinated G Proteins; 2.5 Deubiquitination and Recycling of G proteins; 2.6 G Protein Ubiquitination as a Regulator of Signaling in Yeast; 3 Ubiquitin-Mediated Regulation of Heterotrimeric G Proteins in Mammals; 3.1 Ubiquitination of Transducin; 3.2 Ubiquitination of Gai3; 3.3 Ubiquitination of Gai2; 3.4 Ubiquitination of Gas; 4 Lying in Wait-G Protein Ubiquitination Hotspots With Unknown Function; 5 Concluding Remarks; References
  • Chapter Three - Ubiquitination and Protein Turnover of G Protein-Coupled Receptor Kinases in GPCR Signaling and Cellular RegulationAbstract; 1 Introduction; 2 Ubiquitin-Proteasome Degradation of GRK2: Beyond a Feedback Mechanism of GPCR regulation; 2.1 GRK2 can be Degraded by the Proteasome System; 2.2 GPCR Modulation of GRK2 Stability Depends on Kinase Activity and the Scaffold Role of ß-Arrestins; 2.3 Mdm2 Plays a Central Role in GRK2 Turnover in Both Basal and ß2AR-Stimulation Contexts; 2.4 Other E3-Ligases and Modulators Involved in GPCR-Mediated GRK2 Degradation?
  • 2.5 Mdm2 Serves as Node for Integration of Different Receptor Systems Regulating GRK2 Expression2.6 Modulation of GRK2 Stability During Cell Cycle Progression; 2.7 Potential Modulation of GRK2 Ubiquitination and Stability by Cullin E3-RING Ligase Complexes; 3 Proteasome-Dependent Degradation of Other GRKs; 4 Roles of GRK Ubiquitination Beyond Protein Degradation; 5 Phosphorylation of Ser670 at the Crossroads of GRK2 Regulation: When Does it Signal Protein Degradation?; 6 Multifaceted Roles of the Hsp90 Chaperone in GRK Regulation: The Cardiac Connection
  • 7 GRK Turnover in Ischemic Conditions: Proteasome and Calpains Coshape GPCR Responsiveness
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (431 p.)
Form of item
online
Isbn
9780128093863
Media category
computer
Media MARC source
rdamedia
Specific material designation
remote
System control number
  • (CKB)3710000000737846
  • (EBL)4573701
  • (MiAaPQ)EBC4573701
  • (EXLCZ)993710000000737846
Label
Ubiquitination and transmembrane signaling, edited by Sudha K. Shenoy
Publication
Copyright
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Contents
  • Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter One - Ubiquitination and Deubiquitination of G Protein-Coupled Receptors; Abstract; 1 Introduction; 1.1 G Protein-Coupled Receptors; 1.2 Ubiquitination and Deubiquitination; 2 Ubiquitination of GPCRs; 2.1 ß2 Adrenergic Receptor; 2.2 Chemokine Receptors; 2.2.1 CXCR2; 2.2.2 CXCR4; 2.2.3 CXCR7; 2.2.4 CCR7; 2.3 Proteinase Activated Receptors; 2.3.1 PAR1; 2.3.2 PAR2; 2.4 Opioid Receptors; 2.5 Noncanonical GPCRs and Ubiquitin Ligases; 2.5.1 Wnt/ß-Catenin Signaling; 2.5.2 Hedgehog Signaling; 2.6 Yeast GPCRs
  • 3 Deubiquitination of GPCRs3.1 Overview; 3.2 Recycling and Resensitization; 3.2.1 ß2AR; 3.2.2 PTH1R; 3.2.3 Frizzled and Smoothened; 3.3 Accelerated Degradation; 3.3.1 PAR2; 3.3.2 CXCR4; 3.4 Alternate Effects; 3.4.1 Metabotropic ?-Aminobutyric Acid Receptor (GABABR); 4 Concluding Remarks; Acknowledgments; References; Chapter Two - Heterotrimeric G Protein Ubiquitination as a Regulator of G Protein Signaling; Abstract; 1 Introduction; 2 Ubiquitination of Heterotrimeric G Proteins-Evidence From the Yeast Model System; 2.1 Yeast Ga/Gpa1 as a Model for G Protein Ubiquitination Studies
  • 2.2 Initiating Signals for G Protein Ubiquitination in Yeast2.3 Yeast G Protein Ubiquitin Ligases; 2.4 Trafficking Pathways of Monoubiquitinated G Proteins; 2.5 Deubiquitination and Recycling of G proteins; 2.6 G Protein Ubiquitination as a Regulator of Signaling in Yeast; 3 Ubiquitin-Mediated Regulation of Heterotrimeric G Proteins in Mammals; 3.1 Ubiquitination of Transducin; 3.2 Ubiquitination of Gai3; 3.3 Ubiquitination of Gai2; 3.4 Ubiquitination of Gas; 4 Lying in Wait-G Protein Ubiquitination Hotspots With Unknown Function; 5 Concluding Remarks; References
  • Chapter Three - Ubiquitination and Protein Turnover of G Protein-Coupled Receptor Kinases in GPCR Signaling and Cellular RegulationAbstract; 1 Introduction; 2 Ubiquitin-Proteasome Degradation of GRK2: Beyond a Feedback Mechanism of GPCR regulation; 2.1 GRK2 can be Degraded by the Proteasome System; 2.2 GPCR Modulation of GRK2 Stability Depends on Kinase Activity and the Scaffold Role of ß-Arrestins; 2.3 Mdm2 Plays a Central Role in GRK2 Turnover in Both Basal and ß2AR-Stimulation Contexts; 2.4 Other E3-Ligases and Modulators Involved in GPCR-Mediated GRK2 Degradation?
  • 2.5 Mdm2 Serves as Node for Integration of Different Receptor Systems Regulating GRK2 Expression2.6 Modulation of GRK2 Stability During Cell Cycle Progression; 2.7 Potential Modulation of GRK2 Ubiquitination and Stability by Cullin E3-RING Ligase Complexes; 3 Proteasome-Dependent Degradation of Other GRKs; 4 Roles of GRK Ubiquitination Beyond Protein Degradation; 5 Phosphorylation of Ser670 at the Crossroads of GRK2 Regulation: When Does it Signal Protein Degradation?; 6 Multifaceted Roles of the Hsp90 Chaperone in GRK Regulation: The Cardiac Connection
  • 7 GRK Turnover in Ischemic Conditions: Proteasome and Calpains Coshape GPCR Responsiveness
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (431 p.)
Form of item
online
Isbn
9780128093863
Media category
computer
Media MARC source
rdamedia
Specific material designation
remote
System control number
  • (CKB)3710000000737846
  • (EBL)4573701
  • (MiAaPQ)EBC4573701
  • (EXLCZ)993710000000737846

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