The Resource Vitamins and Hormones, Volume one hundred and one, Klotho, series editor, Gerald Litwack, PhD

Vitamins and Hormones, Volume one hundred and one, Klotho, series editor, Gerald Litwack, PhD

Label
Vitamins and Hormones, Volume one hundred and one, Klotho
Title
Vitamins and Hormones
Title number
Volume one hundred and one
Title part
Klotho
Statement of responsibility
series editor, Gerald Litwack, PhD
Contributor
Editor
Subject
Genre
Language
eng
Member of
Cataloging source
MiAaPQ
Dewey number
572.7
Illustrations
  • illustrations
  • plates
Index
index present
LC call number
QP552.M44
LC item number
.V583 2016
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Litwack, Gerald
Series statement
Vitamins and Hormones,
Series volume
Volume 101
http://library.link/vocab/subjectName
  • Membrane proteins
  • Enzymes
Label
Vitamins and Hormones, Volume one hundred and one, Klotho, series editor, Gerald Litwack, PhD
Instantiates
Publication
Copyright
Note
Description based upon print version of record
Bibliography note
Includes bibiographical references at the end of each chapters and index
Carrier category
online resource
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Contents
  • Front Cover; Klotho; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Klotho-Related Protein KLrP: Structure and Functions; 1. Introduction; 2. The Functions and Crystal Structure of KLrP; 2.1. Metabolic Pathway for GSLs Involving acid GCase GBA1; 2.2. Identification of KLrP as a Novel Cytosolic Neutral GCase; 2.3. KLrP Crystal Structure; 2.4. Mammalian GCases Other than GBA1 and KLrP (GBA3); 3. KLrP and GD; 4. Conclusions and Perspectives; Acknowledgments; References; Chapter Two: The FGF21 Receptor Signaling Complex: Klothoβ, FGFR1c, and Other Regulatory Interactions
  • 1. Introduction2. The Components of the Signaling Complex; 2.1. Klotho-Beta; 2.1.1. The Klotho Family of Receptors; 2.1.2. KLB Structure; 2.1.3. KLB Tissue Expression; 2.2. Fibroblast Growth Factor Receptors; 2.2.1. The Fibroblast Growth Factor Receptor Family; 2.2.2. Fibroblast Growth Factor Receptor Structure; 2.2.3. FGFR1c Tissue Expression; 2.3. Endocrine FGF21; 2.3.1. The Fibroblast Growth Factor Family; 2.3.2. FGF Structure; 2.3.3. Endocrine FGF21 Structure; 2.3.4. Endocrine FGF21 Tissue Expression; 3. Specific Interactions Driving Complex Formation; 3.1. Interaction of FGF21 and KLB
  • 3.2. Interaction of FGF21 and FGFR13.3. Interaction of KLB and FGFR1; 3.4. KLB Domains Relevant for Binding; 4. Stoichiometry of the Signaling Complex; 4.1. Preformed KLB Heterodimers with FGFR1c/4; 5. Other Regulators of the Signaling Complex Formation; 5.1. KLB Inactivation by the Galectin Lattice; 5.2. ECM Regulation of FGFRs; 5.3. Fibroblast Growth Factor Receptor 5; 6. Summary; References; Chapter Three: Klotho-Dependent Cellular Transport Regulation; 1. Introduction; 1.1. Gene Structure and Klotho Protein Types; 1.2. Ectodomain Shedding and Some Functions Mediated by Klotho
  • 1.3. Transport Proteins in the Different Types of Plasma Membrane Transport Systems2. Klotho in the Regulation of Cellular Transport; 2.1. Klotho in the Regulation of Ion Channels; 2.2. Klotho in the Regulation of Carriers; 2.3. Klotho in the Regulation of Na+/K+-ATPase; 3. Conclusion and Future Directions; Acknowledgment; References; Chapter Four: Klotho and the Growth Hormone/Insulin-Like Growth Factor 1 Axis: Novel Insights into Complex Interactions; 1. The Pituitary Gland and the GH/IGF-1 Axis; 1.1. Regulation of GH Transcription and Secretion
  • 1.1.1. Hypothalamic Regulation of GH Secretion1.1.2. Peripheral Regulation of GH Secretion; 1.1.3. Autocrine and Paracrine Regulation of GH Secretion; 1.2. The Activities of GH and IGF-1; 2. Klotho: History, Structure, Functions; 3. Klotho as a Circulating Hormone; 3.1. Available Tests; 3.2. Factor Affecting Circulating Klotho Levels; 3.3. Regulation of Klotho Shedding; 4. Klotho and the Pituitary: Lessons from Mice and Humans; 5. Klotho Regulates GH Secretion; 5.1. Mechanisms of Klotho Activity on GH Secretion; 6. Klotho and the GH/IGF-1 Axis in Humans: Health and Disease States
  • 6.1. Healthy Subjects
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (375 p.)
Form of item
online
Isbn
9780128048191
Media category
computer
Media MARC source
rdamedia
Specific material designation
remote
System control number
  • (CKB)3710000000649829
  • (EBL)4515022
  • (MiAaPQ)EBC4515022
  • (EXLCZ)993710000000649829
Label
Vitamins and Hormones, Volume one hundred and one, Klotho, series editor, Gerald Litwack, PhD
Publication
Copyright
Note
Description based upon print version of record
Bibliography note
Includes bibiographical references at the end of each chapters and index
Carrier category
online resource
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Contents
  • Front Cover; Klotho; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Klotho-Related Protein KLrP: Structure and Functions; 1. Introduction; 2. The Functions and Crystal Structure of KLrP; 2.1. Metabolic Pathway for GSLs Involving acid GCase GBA1; 2.2. Identification of KLrP as a Novel Cytosolic Neutral GCase; 2.3. KLrP Crystal Structure; 2.4. Mammalian GCases Other than GBA1 and KLrP (GBA3); 3. KLrP and GD; 4. Conclusions and Perspectives; Acknowledgments; References; Chapter Two: The FGF21 Receptor Signaling Complex: Klothoβ, FGFR1c, and Other Regulatory Interactions
  • 1. Introduction2. The Components of the Signaling Complex; 2.1. Klotho-Beta; 2.1.1. The Klotho Family of Receptors; 2.1.2. KLB Structure; 2.1.3. KLB Tissue Expression; 2.2. Fibroblast Growth Factor Receptors; 2.2.1. The Fibroblast Growth Factor Receptor Family; 2.2.2. Fibroblast Growth Factor Receptor Structure; 2.2.3. FGFR1c Tissue Expression; 2.3. Endocrine FGF21; 2.3.1. The Fibroblast Growth Factor Family; 2.3.2. FGF Structure; 2.3.3. Endocrine FGF21 Structure; 2.3.4. Endocrine FGF21 Tissue Expression; 3. Specific Interactions Driving Complex Formation; 3.1. Interaction of FGF21 and KLB
  • 3.2. Interaction of FGF21 and FGFR13.3. Interaction of KLB and FGFR1; 3.4. KLB Domains Relevant for Binding; 4. Stoichiometry of the Signaling Complex; 4.1. Preformed KLB Heterodimers with FGFR1c/4; 5. Other Regulators of the Signaling Complex Formation; 5.1. KLB Inactivation by the Galectin Lattice; 5.2. ECM Regulation of FGFRs; 5.3. Fibroblast Growth Factor Receptor 5; 6. Summary; References; Chapter Three: Klotho-Dependent Cellular Transport Regulation; 1. Introduction; 1.1. Gene Structure and Klotho Protein Types; 1.2. Ectodomain Shedding and Some Functions Mediated by Klotho
  • 1.3. Transport Proteins in the Different Types of Plasma Membrane Transport Systems2. Klotho in the Regulation of Cellular Transport; 2.1. Klotho in the Regulation of Ion Channels; 2.2. Klotho in the Regulation of Carriers; 2.3. Klotho in the Regulation of Na+/K+-ATPase; 3. Conclusion and Future Directions; Acknowledgment; References; Chapter Four: Klotho and the Growth Hormone/Insulin-Like Growth Factor 1 Axis: Novel Insights into Complex Interactions; 1. The Pituitary Gland and the GH/IGF-1 Axis; 1.1. Regulation of GH Transcription and Secretion
  • 1.1.1. Hypothalamic Regulation of GH Secretion1.1.2. Peripheral Regulation of GH Secretion; 1.1.3. Autocrine and Paracrine Regulation of GH Secretion; 1.2. The Activities of GH and IGF-1; 2. Klotho: History, Structure, Functions; 3. Klotho as a Circulating Hormone; 3.1. Available Tests; 3.2. Factor Affecting Circulating Klotho Levels; 3.3. Regulation of Klotho Shedding; 4. Klotho and the Pituitary: Lessons from Mice and Humans; 5. Klotho Regulates GH Secretion; 5.1. Mechanisms of Klotho Activity on GH Secretion; 6. Klotho and the GH/IGF-1 Axis in Humans: Health and Disease States
  • 6.1. Healthy Subjects
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (375 p.)
Form of item
online
Isbn
9780128048191
Media category
computer
Media MARC source
rdamedia
Specific material designation
remote
System control number
  • (CKB)3710000000649829
  • (EBL)4515022
  • (MiAaPQ)EBC4515022
  • (EXLCZ)993710000000649829

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